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    Sc2 Sc2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sc2provided by FlyBase
    Official Full Name
    Sc2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035471
    Locus tag
    Dmel_CG10849
    See related
    AllianceGenome:FB:FBgn0035471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10849; Dmel\CG10849; dSc2; l(3)05634; l(3)63Eb; l(3)SH4; SC2; Ter[CG10849]
    Summary
    Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in very long-chain fatty acid biosynthetic process. Located in cytoplasm and endomembrane system. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14 and catecholaminergic polymorphic ventricular tachycardia 3. Orthologous to several human genes including TECR (trans-2,3-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Sc2 in Genome Data Viewer
    Location:
    63F5-63F6; 3-9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3903492..3905035)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3903492..3905035)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene Caffeine, calcium, zinc sensitivity 1 Neighboring gene Ubiquitin-63E Neighboring gene imaginal discs arrested Neighboring gene maggie

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic characterization of Drosophila ida mutants: defining the role of APC5 in cell cycle progression. Bentley AM, et al. J Cell Sci, 2002 Mar 1. PMID 11870214
    2. A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila. Patch K, et al. PLoS One, 2009 Oct 23. PMID 19862331, Free PMC Article
    3. Genetic analysis of the Drosophila 63F early puff. Characterization of mutations in E63-1 and maggie, a putative Tom22. Vaskova M, et al. Genetics, 2000 Sep. PMID 10978288, Free PMC Article
    4. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Chen H, et al. Hum Mol Genet, 2010 Feb 1. PMID 19933170
    5. A modifier screen in the eye reveals control genes for Krüppel activity in the Drosophila embryo. Carrera P, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724781, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain enoyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    Sc2
    Names
    CG10849-PA
    Sc2-PA
    Ubiquitin-63E
    lethal(3)63Eb
    NP_647836.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3903492..3905035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139579.3 → NP_647836.2  Sc2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647836.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDR5, Q9VZL3
      Related
      FBpp0073017
      Conserved Domains (3) summary
      cd01801
      Location:3 → 79
      Tsc13_N; Ubiquitin-like domain of Tsc13
      PLN02560
      Location:15 → 299
      PLN02560; enoyl-CoA reductase
      cl21511
      Location:150 → 302
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R45 Q95R45
    Q9VZL3 Q9VZL3

    Gene LinkOut

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