Sema1a Semaphorin 1a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sema1aprovided by FlyBase
Official Full Name: Semaphorin 1aprovided by FlyBase
Primary source: FLYBASE:FBgn0011259
Locus tag: Dmel_CG18405
See related: AllianceGenome:FB:FBgn0011259
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE36155; CG18405; CT26404; D-Sema 1a; d-sema I; D-Sema I; D-Sema-I; d-semaI; D-semaI; D-SemaI; Dmel\CG18405; Dsema 1a; Dsema-I; Fas-IV; FasIV; l(2)k13702; sema; sema 1a; Sema 1a; sema-1a; Sema-1a; SEMA-1A; sema-I; Sema-I; sema1a; Sema1A; SemaI
Summary: Enables heparin binding activity. Involved in several processes, including negative regulation of cell size; neuron development; and semaphorin-plexin signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; large field neuron of the central complex; neuromere; and synaptic neuropil domain. Orthologous to human SEMA6A (semaphorin 6A) and SEMA6C (semaphorin 6C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 29E1-29E3; 2-33 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8542147..8672041)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8542147..8672041)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isoforms of terminal selector Mamo control axon guidance during adult Drosophila memory center construction via Semaphorin-1a.
Title: Isoforms of terminal selector Mamo control axon guidance during adult Drosophila memory center construction via Semaphorin-1a.
The PDZ domain binding motif found in the most C-terminal region of the Sema-1a ICD is necessary for interaction with Vari, but not Cher, indicative of distinct binding modalities. Pbl/Sema-1a-mediated repulsive guidance is potentiated by both vari and cher Genetic analyses further suggest that scaffolding functions of Vari and Cher play an important role in Pbl-mediated Sema-1a reverse signaling.
Title: Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling in Drosophila.
The transmembrane proteins semaphorin-1a (Sema-1a) and plexin A function together to regulate ellipsoid body laminated ring (R) neuron axon lamination.
Title: The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections.
Sema-1a reverse signaling can elicit distinct axonal responses depending on differential engagement of distinct ligands and signaling effectors.
Title: Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins.
Sema1a and Dscam1 might play essential roles in the Drosophila DA1 ventral olfactory projection neurons morphogenesis.
Title: Morphogenetic Studies of the Drosophila DA1 Ventral Olfactory Projection Neuron.
these results demonstrate that Sema-1a repulsion keeps dendrites of different types of PNs away from each other, enabling the same types of PN dendrites to be sorted into destined AL glomeruli and permitting for functional assembly of olfactory circuitry.
Title: Semaphorin-1a prevents Drosophila olfactory projection neuron dendrites from mis-targeting into select antennal lobe regions.
The authors show that PlexA/Sema1a mediates motoneuron axon branching in ways that differ in the proximal femur and distal tibia, based on motoneuronal birth order.
Title: Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking.
A novel mechanism underlying upregulation of axon-axon attraction by Semaphorin-1a (Sema1a) reverse signaling in the developing Drosophila visual system, is reported.
Title: Control of axon-axon attraction by Semaphorin reverse signaling.
This study demonistrated that the transmembrane guidance cue Sema-1a regulates axon-axon interactions, providing insight into links between guidance cue recognition and subsequent intracellular signaling events.
Title: The Control of semaphorin-1a-mediated reverse signaling by opposing pebble and RhoGAPp190 functions in drosophila.
Sema1a and netrin A can specifically promote growth through induction of key cellular growth regulators.
Title: Induction of cellular growth by the axon guidance regulators netrin A and semaphorin-1a.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: semaphorin 1a

Names: CG18405-PA; CG18405-PD; CG18405-PE; CG18405-PF; CG18405-PG; CG18405-PH; CG18405-PI; Fasciclin-IV; Sema-1a; Sema1a-PA; Sema1a-PD; Sema1a-PE; Sema1a-PF; Sema1a-PG; Sema1a-PH; Sema1a-PI; Semaphorin-1; Semaphorin-1A; semaphorin; semaphorin 1; semaphorin I; semaphorin1a; semiphorin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8542147..8672041

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135399.5 → NP_609243.3 semaphorin 1a, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609243.3

Status: REVIEWED

UniProtKB/TrEMBL

Q0E8S4

Conserved Domains (2) summary

cd11237
Location:91 → 546

Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)

smart00423
Location:545 → 579

PSI; domain found in Plexins, Semaphorins and Integrins
NM_001201802.2 → NP_001188731.1 semaphorin 1a, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188731.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E8S4

Conserved Domains (2) summary

cd11237
Location:91 → 546

Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)

smart00423
Location:545 → 579

PSI; domain found in Plexins, Semaphorins and Integrins
NM_001273337.1 → NP_001260266.1 semaphorin 1a, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260266.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFA5

Conserved Domains (2) summary

cd11237
Location:91 → 546

Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)

smart00423
Location:545 → 579

PSI; domain found in Plexins, Semaphorins and Integrins
NM_001201803.2 → NP_001188732.1 semaphorin 1a, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188732.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRI2

Conserved Domains (2) summary

cd11237
Location:91 → 546

Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)

smart00423
Location:545 → 579

PSI; domain found in Plexins, Semaphorins and Integrins
NM_001273338.1 → NP_001260267.1 semaphorin 1a, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260267.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PB77

Conserved Domains (2) summary

cd11237
Location:91 → 546

Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)

smart00423
Location:545 → 579

PSI; domain found in Plexins, Semaphorins and Integrins
NM_001273336.1 → NP_001260265.1 semaphorin 1a, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260265.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCL7

Conserved Domains (2) summary

cd11237
Location:91 → 546

Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)

smart00423
Location:545 → 579

PSI; domain found in Plexins, Semaphorins and Integrins
NM_164830.5 → NP_723407.2 semaphorin 1a, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723407.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24322, Q8MYZ9

Related

FBpp0079302

Conserved Domains (2) summary

cd11237
Location:91 → 546

Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)

smart00423
Location:545 → 579

PSI; domain found in Plexins, Semaphorins and Integrins