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    Cyp9b2 Cytochrome P450 9b2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp9b2provided by FlyBase
    Official Full Name
    Cytochrome P450 9b2provided by FlyBase
    Primary source
    FLYBASE:FBgn0015039
    Locus tag
    Dmel_CG4486
    See related
    AllianceGenome:FB:FBgn0015039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    9b2; BEST:GH08116; CG4486; cyp9b2; Cyp9B2; CYP9B2; Dmel\CG4486; P-450; P-450 Cyp9b2; P450
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic midgut chamber; embryonic/larval Malpighian tubule; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp9b2 in Genome Data Viewer
    Location:
    42F2-42F2; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7130277..7132139, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3017782..3019644, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-AGT 1-2 Neighboring gene uncharacterized protein Neighboring gene espinas Neighboring gene long non-coding RNA:CR44443 Neighboring gene Cytochrome P450 9b1 Neighboring gene Serpin 43Aa Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loci Contributing to Boric Acid Toxicity in Two Reference Populations of Drosophila melanogaster. Najarro MA, et al. G3 (Bethesda), 2017 Jun 7. PMID 28592646, Free PMC Article
    2. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871
    3. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Keogh DP, et al. Experientia, 1992 Jan 15. PMID 1737575
    4. Alkaloid metabolism by cytochrome P-450 enzymes in Drosophila melanogaster. Danielson PB, et al. Comp Biochem Physiol B Biochem Mol Biol, 1995 Apr. PMID 7749620
    5. [Ethanol inhibits recombination in somatic cells of gamma-irradiated larvae of Drosophila melanogaster]. Zakharenko LP, et al. Genetika, 1998 Mar. PMID 9589864

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 9b2
    Names
    CG4486-PA
    Cyp9b2-PA
    cytochrome P450
    cytochrome P450-9b2
    fly plexin a
    NP_523646.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7130277..7132139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078922.4 → NP_523646.1  cytochrome P450 9b2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523646.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24123, Q9V4I1
      Related
      FBpp0088126
      Conserved Domains (1) summary
      cl12078
      Location:37 → 478
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4I1.1 Q9V4I1

    Gene LinkOut

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