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    Cdep Chondrocyte-derived ezrin-like domain containing protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40608, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cdepprovided by FlyBase
    Official Full Name
    Chondrocyte-derived ezrin-like domain containing proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265082
    Locus tag
    Dmel_CG44193
    See related
    AllianceGenome:FB:FBgn0265082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT26639; BcDNA:RH50880; cdep; CDEP; CG1283; CG2008; CG31536; CG34306; CG44193; Dmel\CG44193; i23
    Old locus tag
    Dmel_CG31536; Dmel_CG34306
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Rac protein signal transduction. Predicted to be located in cytoskeleton. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; larval muscle cell; and trunk visceral muscle primordium. Human ortholog(s) of this gene implicated in congenital nystagmus 1. Orthologous to human FRMD7 (FERM domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdep in Genome Data Viewer
    Location:
    82E2-82E3; 3-47.1 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4910552..4945576)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (736274..771298)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45580 Neighboring gene Germ line transcription factor 1 Neighboring gene long non-coding RNA:CR45188 Neighboring gene small nuclear RNA U1 at 82Eb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes. Malko DB, et al. Genome Res, 2006 Apr. PMID 16520458, Free PMC Article
    2. A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells. Nagarkar-Jaiswal S, et al. Elife, 2017 May 31. PMID 28561736, Free PMC Article
    3. Drosophila Yurt is a new protein-4.1-like protein required for epithelial morphogenesis. Hoover KB, et al. Dev Genes Evol, 2002 Jun. PMID 12070613
    4. A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7. Zahoor MK, et al. Mol Genet Genomics, 2019 Jun. PMID 30656413
    5. A Scribble/Cdep/Rac pathway controls follower-cell crawling and cluster cohesion during collective border-cell migration. Campanale JP, et al. Dev Cell, 2022 Nov 7. PMID 36347240, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 4942976-4944718 mobile_element_type = transposon:Tc3{}5089

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chondrocyte-derived ezrin-like domain containing protein
    Names
    CG44193-PC
    CG44193-PE
    CG44193-PF
    CG44193-PG
    Cdep-PC
    Cdep-PE
    Cdep-PF
    Cdep-PG
    Chondrocyte-derived ezrin-like domain containing protein ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4910552..4945576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043211.2 → NP_001036676.1  Chondrocyte-derived ezrin-like domain containing protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2M1E6
      Conserved Domains (9) summary
      smart00295
      Location:70 → 264
      B41; Band 4.1 homologues
      cd00160
      Location:659 → 838
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:863 → 965
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:251 → 372
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:1055 → 1151
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      cd14473
      Location:163 → 256
      FERM_B-lobe; FERM domain B-lobe
      pfam00169
      Location:1059 → 1149
      PH; PH domain
      pfam08736
      Location:364 → 406
      FA; FERM adjacent (FA)
      pfam09379
      Location:73 → 134
      FERM_N; FERM N-terminal domain

    2. NM_169022.2 → NP_730882.2  Chondrocyte-derived ezrin-like domain containing protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730882.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHA1
      Conserved Domains (9) summary
      smart00295
      Location:70 → 264
      B41; Band 4.1 homologues
      cd00160
      Location:655 → 834
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:859 → 961
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:251 → 368
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:1051 → 1147
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      cd14473
      Location:163 → 256
      FERM_B-lobe; FERM domain B-lobe
      pfam00169
      Location:1055 → 1145
      PH; PH domain
      pfam08736
      Location:360 → 402
      FA; FERM adjacent (FA)
      pfam09379
      Location:73 → 134
      FERM_N; FERM N-terminal domain

    3. NM_001104215.2 → NP_001097685.2  Chondrocyte-derived ezrin-like domain containing protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097685.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQT5
      Conserved Domains (5) summary
      smart00295
      Location:70 → 264
      B41; Band 4.1 homologues
      cd13193
      Location:251 → 372
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd14473
      Location:163 → 256
      FERM_B-lobe; FERM domain B-lobe
      pfam08736
      Location:364 → 406
      FA; FERM adjacent (FA)
      pfam09379
      Location:73 → 134
      FERM_N; FERM N-terminal domain

    4. NM_141248.4 → NP_649505.1  Chondrocyte-derived ezrin-like domain containing protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SU0, Q9VN68
      Related
      FBpp0307779
      Conserved Domains (5) summary
      smart00295
      Location:70 → 264
      B41; Band 4.1 homologues
      cd13193
      Location:251 → 372
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd14473
      Location:163 → 256
      FERM_B-lobe; FERM domain B-lobe
      pfam08736
      Location:364 → 399
      FA; FERM adjacent (FA)
      pfam09379
      Location:73 → 134
      FERM_N; FERM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHA1 A0A0C4DHA1
    A8JQT5 A8JQT5
    Q2M1E6 Q2M1E6
    Q8MSL4 Q8MSL4
    Q8SWZ7 Q8SWZ7
    Q9VN68 Q9VN68

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