Ankle2 Ankle2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ankle2provided by FlyBase
Official Full Name: Ankle2provided by FlyBase
Primary source: FLYBASE:FBgn0028343
Locus tag: Dmel_CG8465
See related: AllianceGenome:FB:FBgn0028343
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Ankle-2; anon-WO03040301.175; anon-WO03040301.177; anon-WO03040301.179; CG8465; dAnkle2; Dmel\CG8465; l(1)G0222; l(1)G0316
Summary: Predicted to enable protein phosphatase 2A binding activity. Predicted to be involved in mitotic nuclear membrane reassembly. Located in endoplasmic reticulum and nuclear envelope. Is expressed in adult brain cell body rind; central brain primordium; embryonic brain; and organism. Used to study microcephaly and primary autosomal recessive microcephaly 16. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 16B5-16B6; 1-57 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17571854..17579229, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17465887..17473262, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitotic nuclear membrane reassembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ankle2

Names: ANKLE2 ortholog; Ankle2-PD; Ankle2-PE; Ankle2-PF; Ankle2-PG; CG8465-PD; CG8465-PE; CG8465-PF; CG8465-PG; ankyrin repeat and LEM domain containing 2; l(1)G0222; lethal (1) G0222

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

17571854..17579229 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298446.1 → NP_001285375.1 Ankle2, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285375.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCC5

Conserved Domains (3) summary

cd00204
Location:243 → 375

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:282 → 361

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:280 → 335

ANK; ANK repeat [structural motif]
NM_132993.3 → NP_573221.2 Ankle2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573221.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHR1, Q8MQX9, Q9VX44, X2JCC5

Conserved Domains (2) summary

sd00045
Location:280 → 335

ANK; ANK repeat [structural motif]

pfam12796
Location:281 → 361

Ank_2; Ankyrin repeats (3 copies)
NM_167569.2 → NP_728082.2 Ankle2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728082.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHR1, Q8MQX9, Q9VX44, X2JCC5

Conserved Domains (2) summary

sd00045
Location:280 → 335

ANK; ANK repeat [structural motif]

pfam12796
Location:281 → 361

Ank_2; Ankyrin repeats (3 copies)
NM_167570.2 → NP_728083.2 Ankle2, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728083.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VX44

Conserved Domains (3) summary

cd00204
Location:179 → 311

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:218 → 297

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:216 → 271

ANK; ANK repeat [structural motif]