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    prg piragua [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prgprovided by FlyBase
    Official Full Name
    piraguaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285971
    Locus tag
    Dmel_CG9233
    See related
    AllianceGenome:FB:FBgn0285971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9233; Dmel\CG9233; FU12; fu2; pra; Prg
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dorsal closure and head involution. Predicted to be located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germ layer; germline cell; and imaginal disc. Orthologous to human ZNF646 (zinc finger protein 646). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prg in Genome Data Viewer
    Location:
    29D1-29D1; 2-33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8464488..8466694)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8464488..8466694)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Aminoadipate-semialdehyde dehydrogenase Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene dachs Neighboring gene transfer RNA:Aspartic acid-GTC 1-2 Neighboring gene Chemosensory protein A 29a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Piragua Gene Is not Essential for Drosophila Development. Sokolov VV, et al. Dokl Biol Sci, 2021 Nov. PMID 34962606
    2. piragua encodes a zinc finger protein required for development in Drosophila. Nazario-Yepiz NO, et al. Mech Dev, 2017 Apr. PMID 28011160
    3. Extremely rapid and reversible optogenetic perturbation of nuclear proteins in living embryos. Kögler AC, et al. Dev Cell, 2021 Aug 23. PMID 34363757, Free PMC Article
    4. GeneFizz: A web tool to compare genetic (coding/non-coding) and physical (helix/coil) segmentations of DNA sequences. Gene discovery and evolutionary perspectives. Yeramian E, et al. Nucleic Acids Res, 2003 Jul 1. PMID 12824434, Free PMC Article
    5. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Rhiner C, et al. Dev Cell, 2010 Jun 15. PMID 20627080

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Piragua Gene Is not Essential for Drosophila Development.
      Title: The Piragua Gene Is not Essential for Drosophila Development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    piragua
    Names
    CG9233-PA
    CG9233-PB
    fu2
    prg-PA
    prg-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8464488..8466694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273324.2 → NP_001260253.1  piragua, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260253.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLK8
      UniProtKB/TrEMBL
      Q9U1J8
      Conserved Domains (5) summary
      COG5048
      Location:212 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294 → 316
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:16 → 94
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:308 → 331
      zf-H2C2_2; Zinc-finger double domain

    2. NM_135388.5 → NP_609232.2  piragua, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609232.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLK8
      UniProtKB/TrEMBL
      Q9U1J8
      Related
      FBpp0079289
      Conserved Domains (5) summary
      COG5048
      Location:212 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294 → 316
      zf-C2H2; Zinc finger, C2H2 type
      pfam07776
      Location:16 → 94
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:308 → 331
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZP9 Q8SZP9
    Q9U1J8 Q9U1J8
    Q9VLK8 Q9VLK8
    Q9VLK8.2

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