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    dpr5 defective proboscis extension response 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpr5provided by FlyBase
    Official Full Name
    defective proboscis extension response 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0037908
    Locus tag
    Dmel_CG5308
    See related
    AllianceGenome:FB:FBgn0037908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5308; CT16895; Dmel\CG5308; Dpr-5; Dpr5
    Summary
    Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dpr5 in Genome Data Viewer
    Location:
    86E7-86E8; 3-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11499984..11505951)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7325706..7331673)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein LB Neighboring gene long non-coding RNA:CR45581 Neighboring gene antisense RNA:CR45056 Neighboring gene defective proboscis extension response 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila. Pérez-Moreno JJ, et al. G3 (Bethesda), 2019 Feb 7. PMID 30530644, Free PMC Article
    2. The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains. Oyarce-Pezoa S, et al. Sci Rep, 2023 Oct 10. PMID 37816871, Free PMC Article
    3. Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons. Bornstein B, et al. EMBO J, 2021 Jun 15. PMID 33847376, Free PMC Article
    4. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Gerken AR, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25805817, Free PMC Article
    5. Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. Barish S, et al. PLoS Genet, 2018 Aug. PMID 30102700, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory perception of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    defective proboscis extension response 5
    Names
    CG5308-PA
    CG5308-PB
    dpr5-PA
    dpr5-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11499984..11505951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141823.3 → NP_650080.3  defective proboscis extension response 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650080.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961T8, Q9VGN0
      Related
      FBpp0081870
      Conserved Domains (3) summary
      cd00096
      Location:211 → 278
      Ig; Immunoglobulin domain
      smart00410
      Location:206 → 278
      IG_like; Immunoglobulin like
      pfam07686
      Location:95 → 191
      V-set; Immunoglobulin V-set domain

    2. NM_169395.2 → NP_731580.1  defective proboscis extension response 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INK5
      Related
      FBpp0081871
      Conserved Domains (3) summary
      cd00096
      Location:173 → 240
      Ig; Immunoglobulin domain
      smart00410
      Location:168 → 240
      IG_like; Immunoglobulin like
      pfam07686
      Location:57 → 153
      V-set; Immunoglobulin V-set domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8INK5 Q8INK5
    Q961T8 Q961T8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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