Aladin aladin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Aladinprovided by FlyBase
Official Full Name: aladinprovided by FlyBase
Primary source: FLYBASE:FBgn0030122
Locus tag: Dmel_CG16892
See related: AllianceGenome:FB:FBgn0030122
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: aladin; ALADIN; CG16892; Dmel\CG16892
Summary: Involved in microtubule bundle formation; mitotic spindle assembly; and positive regulation of protein localization to spindle pole body. Located in mitotic spindle and spindle pole. Is expressed in adult head. Human ortholog(s) of this gene implicated in achalasia and triple-A syndrome. Orthologous to human AAAS (aladin WD repeat nucleoporin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9273413..9275653)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9167446..9169686)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in microtubule bundle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleocytoplasmic transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to spindle pole body	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

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