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    l(3)72Dp lethal (3) 72Dp [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(3)72Dpprovided by FlyBase
    Official Full Name
    lethal (3) 72Dpprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263607
    Locus tag
    Dmel_CG32155
    See related
    AllianceGenome:FB:FBgn0263607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32155; CG5082; Dmel\CG32155
    Summary
    Predicted to enable gamma-glutamyl-peptidase activity. Predicted to be involved in tetrahydrofolylpolyglutamate metabolic process. Predicted to be active in vacuole. Is expressed in adult head. Orthologous to human GGH (gamma-glutamyl hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)72Dp in Genome Data Viewer
    Location:
    72D10-72D10; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16234140..16236999)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16227240..16230099)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Thioredoxin-related transmembrane protein 3 Neighboring gene Programmed Cell Death 5 Neighboring gene Mediator complex subunit 10 Neighboring gene Heat shock protein cognate 20 Neighboring gene lethal (3) 72Dr Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article
    2. Anent the genomics of spermatogenesis in Drosophila melanogaster. Lindsley DL, et al. PLoS One, 2013. PMID 23409089, Free PMC Article
    3. Drosophila Relish Activating lncRNA-CR33942 Transcription Facilitates Antimicrobial Peptide Expression in Imd Innate Immune Response. Zhou H, et al. Front Immunol, 2022. PMID 35720331, Free PMC Article
    4. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
    5. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-glutamyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables omega peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tetrahydrofolylpolyglutamate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (3) 72Dp
    Names
    CG32155-PA
    l(3)72Dp-PA
    NP_730119.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16234140..16236999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168655.3 → NP_730119.1  lethal (3) 72Dp [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730119.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BIC6, Q8IQM9
      Related
      FBpp0075214
      Conserved Domains (2) summary
      cd01747
      Location:28 → 303
      GATase1_Glutamyl_Hydrolase; Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
      pfam07722
      Location:26 → 244
      Peptidase_C26; Peptidase C26
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BIC6 Q5BIC6
    Q8IQM9 Q8IQM9

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