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    Rpe Ribulose-5-phosphate-3-epimerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35692, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rpeprovided by FlyBase
    Official Full Name
    Ribulose-5-phosphate-3-epimeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050499
    Locus tag
    Dmel_CG30499
    See related
    AllianceGenome:FB:FBgn0050499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1364; CG30499; Dmel\CG30499
    Summary
    Enables D-ribulose-phosphate 3-epimerase activity. Involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be active in cytosol. Is expressed in adult head and organism. Orthologous to several human genes including RPEL1 (ribulose-5-phosphate-3-epimerase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpe in Genome Data Viewer
    Location:
    43D7-43D7; 2-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7564434..7565751, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3451939..3453256, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome b5 Neighboring gene Glycerophosphate oxidase 2 Neighboring gene uncharacterized protein Neighboring gene corin Neighboring gene boca Neighboring gene Vacuolar protein sorting 13 Neighboring gene antisense RNA:CR45130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pentose shunt in wild-type and glucose-6-phosphate dehydrogenase deficient Drosophila melanogaster. Geer BW, et al. J Exp Zool, 1974 Jan. PMID 4149211
    2. Chromosomal instability causes sensitivity to protein folding stress and ATP depletion. Khan M, et al. Biol Open, 2018 Oct 16. PMID 30327366, Free PMC Article
    3. Potential involvement of Drosophila flightless-1 in carbohydrate metabolism. Park JE, et al. BMB Rep, 2018 Sep. PMID 30060781, Free PMC Article
    4. Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Whitaker R, et al. Aging (Albany NY), 2014 May. PMID 24864304, Free PMC Article
    5. Chromosomal instability causes sensitivity to metabolic stress. Shaukat Z, et al. Oncogene, 2015 Jul 30. PMID 25347746

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-ribulose-phosphate 3-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-ribulose-phosphate 3-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-ribulose-phosphate 3-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ribulose-5-phosphate-3-epimerase
    Names
    CG30499-PA
    CG30499-PB
    Rpe-PA
    Rpe-PB
    ribulose phosphate 3-epimerase
    NP_001260780.1
    NP_610298.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7564434..7565751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136454.3 → NP_610298.2  Ribulose-5-phosphate-3-epimerase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610298.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RV5
      Related
      FBpp0088028
      Conserved Domains (1) summary
      cd00429
      Location:6 → 213
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    2. NM_001273851.1 → NP_001260780.1  Ribulose-5-phosphate-3-epimerase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RV5
      Conserved Domains (1) summary
      cd00429
      Location:6 → 213
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RV5 Q95RV5

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