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    Cht7 Chitinase 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38370, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cht7provided by FlyBase
    Official Full Name
    Chitinase 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0035398
    Locus tag
    Dmel_CG1869
    See related
    AllianceGenome:FB:FBgn0035398
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1869; Cht; cht7; DmCht7; DmCHT7; Dmel\CG1869
    Summary
    Enables chitinase activity. Involved in several processes, including chitin catabolic process; ecdysis, chitin-based cuticle; and regulation of tube architecture, open tracheal system. Predicted to be active in extracellular region. Is expressed in adult head. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Cht7 in Genome Data Viewer
    Location:
    63B1-63B1; 3-6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3090985..3106958, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3090985..3106958, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Poly(A) specific ribonuclease subunit PAN3 Neighboring gene small nuclear RNA U5 at 63BC Neighboring gene transfer RNA:Cysteine-GCA 1-1 Neighboring gene transfer RNA:Lysine-CTT 1-12 Neighboring gene transfer RNA:Cysteine-GCA 1-2 Neighboring gene transfer RNA:Lysine-CTT 1-13 Neighboring gene transfer RNA:Cysteine-GCA 1-3 Neighboring gene transfer RNA:Cysteine-GCA 1-4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene prominin-like

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding  
    enables chitinase activity  
    enables chitinase activity PubMed 
    enables hydrolase activity, hydrolyzing O-glycosyl compounds  
    Component Evidence Code Pubs
    is_active_in extracellular region  
    located_in extracellular region  

    General protein information

    Preferred Names
    chitinase 7
    Names
    CG1869-PA
    Cht7-PA
    NP_647768.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3090985..3106958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139511.4 → NP_647768.3  chitinase 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647768.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960M0, Q9VZV2
      Conserved Domains (3) summary
      cd02872
      Location:125 → 491
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:124 → 468
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:951 → 1005
      CBM_14; Chitin binding Peritrophin-A domain
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