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    Myo31DF Myosin 31DF [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myo31DFprovided by FlyBase
    Official Full Name
    Myosin 31DFprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086347
    Locus tag
    Dmel_CG7438
    See related
    AllianceGenome:FB:FBgn0086347
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7438; Dm IA; Dmel\CG7438; DmIA; DroMIA; IA; mhc1; Mhc1; Myo-IA; Myo1a; Myo1A; myo1D; Myo1D; myo31DF; MyoIA; MYOIA; myoID; MyoID; souther
    Summary
    Enables microfilament motor activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in digestive tract development; imaginal disc-derived male genitalia morphogenesis; and mesoderm development. Located in cell cortex. Is expressed in several structures, including embryonic/larval midgut primordium; enterocyte; glomerulus; gut section; and larval imaginal tissue. Orthologous to several human genes including MYO1G (myosin IG). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Myo31DF in Genome Data Viewer
    Location:
    31F1-31F4; 2-43 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10491814..10506779, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10491814..10506779, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Grip75 Neighboring gene Component of oligomeric golgi complex 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44224 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fatty acid transport protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Left-right asymmetry is formed in individual cells by intrinsic cell chirality. Hatori R, et al. Mech Dev, 2014 Aug. PMID 24800645
    2. Proper direction of male genitalia is prerequisite for copulation in Drosophila, implying cooperative evolution between genitalia rotation and mating behavior. Inatomi M, et al. Sci Rep, 2019 Jan 18. PMID 30659250, Free PMC Article
    3. Left-right Myosin-Is, Myosin1C, and Myosin1D exhibit distinct single molecule behaviors on the plasma membrane of Drosophila macrophages. Utsunomiya S, et al. Genes Cells, 2024 May. PMID 38454557
    4. Characterization of myosin-IA and myosin-IB, two unconventional myosins associated with the Drosophila brush border cytoskeleton. Morgan NS, et al. Dev Biol, 1995 Nov. PMID 7589814
    5. The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. Morgan NS, et al. J Mol Biol, 1994 Jun 10. PMID 8201616

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results reveal the molecular motor Myo1D as a chiral determinant that is sufficient to break symmetry at all biological scales through chiral interaction with the actin cytoskeleton.
      Title: Molecular to organismal chirality is induced by the conserved myosin 1D.
    2. Myo31DF-overexpressing cells suggest that cell-shape chirality was established in each cell and reflects intrinsic planar cell chirality.
      Title: Left-right asymmetry is formed in individual cells by intrinsic cell chirality.
    3. DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment.
      Title: DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment.
    4. left-right(LR)directional rotation of hindgut epithelial tube; DECad is distributed to cell boundaries with LR asymmetry which is responsible for planar cell-shape chirality formation; myosin ID switches LR polarity found in PCC and in DE-Cad distribution
      Title: Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis.
    5. the organ specificities of the Myo31DF and Myo61F activities depended on their head regions
      Title: Head region of unconventional myosin I family members is responsible for the organ-specificity of their roles in left-right polarity in Drosophila.
    6. Myo31DF interacts and colocalizes with beta-catenin, suggesting that situs inversus genes can direct left-right development through the adherens junction
      Title: Type ID unconventional myosin controls left-right asymmetry in Drosophila.
    7. the actin cytoskeleton and myosin I proteins may be crucial for generating left-right asymmetry in invertebrates
      Title: An unconventional myosin in Drosophila reverses the default handedness in visceral organs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microfilament motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of digestive tract left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hindgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin 31DF
    Names
    CG7438-PA
    CG7438-PB
    CG7438-PC
    Myo31DF-PA
    Myo31DF-PB
    Myo31DF-PC
    Myosin31DF
    myosin 1D
    myosin 1a
    myosin I
    myosin IA
    myosin ID
    myosin-IA
    myosin1A
    souther
    type ID unconventional myosin 31DF
    unconventional myosin 31DF
    NP_001188784.1
    NP_523538.1
    NP_723596.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10491814..10506779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078814.4 → NP_523538.1  myosin 31DF, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0K5, M9MRS7, Q23978
      Related
      FBpp0079625
      Conserved Domains (3) summary
      smart00242
      Location:6 → 690
      MYSc; Myosin. Large ATPases
      cd01378
      Location:21 → 677
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:801 → 983
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. NM_001201855.2 → NP_001188784.1  myosin 31DF, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188784.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0K5, M9MRS7, Q23978
      Conserved Domains (3) summary
      smart00242
      Location:6 → 690
      MYSc; Myosin. Large ATPases
      cd01378
      Location:21 → 677
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:801 → 983
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    3. NM_164933.3 → NP_723596.1  myosin 31DF, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0K5, M9MRS7, Q23978
      Related
      FBpp0079626
      Conserved Domains (3) summary
      smart00242
      Location:6 → 690
      MYSc; Myosin. Large ATPases
      cd01378
      Location:21 → 677
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:801 → 983
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23978.1 Q23978

    Gene LinkOut

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