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    Cyp4g1 Cytochrome P450 4g1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 30986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4g1provided by FlyBase
    Official Full Name
    Cytochrome P450 4g1provided by FlyBase
    Primary source
    FLYBASE:FBgn0010019
    Locus tag
    Dmel_CG3972
    See related
    AllianceGenome:FB:FBgn0010019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4g1; anon-WO0140519.102; ASC-T1; CG3972; cyp4g1; Cyp4G1; CYP4G1; Cyt-P450-A1; Dmel\CG3972; EG:165H7.1; P-450; P-450-A; P450; P450-A; P450A; scgamma; T1
    Summary
    Enables carbon-carbon lyase activity. Involved in cuticle hydrocarbon biosynthetic process. Is expressed in several structures, including adult head; adult heart; embryonic/larval oenocyte; prothoracic gland; and ring gland. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4g1 in Genome Data Viewer
    Location:
    1B4-1B4; 1-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (467057..469335, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (361090..363368, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pepsinogen C-like Neighboring gene asense Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene ellipsoid body open

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of insecticide resistance-related forms of cytochrome P-450 from Drosophila melanogaster. Sundseth SS, et al. Biochem J, 1990 Jan 1. PMID 2105716, Free PMC Article
    2. Two functionally distinct CYP4G genes of Anopheles gambiae contribute to cuticular hydrocarbon biosynthesis. Kefi M, et al. Insect Biochem Mol Biol, 2019 Jul. PMID 31051237
    3. Possible involvement of the long terminal repeat of transposable element 17.6 in regulating expression of an insecticide resistance-associated P450 gene in Drosophila. Waters LC, et al. Proc Natl Acad Sci U S A, 1992 Jun 1. PMID 1317576, Free PMC Article
    4. A single p450 allele associated with insecticide resistance in Drosophila. Daborn PJ, et al. Science, 2002 Sep 27. PMID 12351787
    5. Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons. Wang Z, et al. Elife, 2022 Dec 6. PMID 36473178, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbon-carbon lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cuticle hydrocarbon biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 4g1
    Names
    Achaete-scute complex transcript 1
    CG3972-PA
    Cyp4g1-PA
    cytochrome P450
    cytochrome P450 A1
    cytochrome P450-4g1
    NP_525031.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      467057..469335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080292.4 → NP_525031.1  cytochrome P450 4g1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UN25, Q24126, Q95U60, Q9V3S0
      Related
      FBpp0070094
      Conserved Domains (1) summary
      pfam00067
      Location:58 → 518
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3S0.1 Q9V3S0

    Gene LinkOut

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