Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grin2cprovided by MGI
Official Full Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3)provided by MGI
Primary source: MGI:MGI:95822
See related: Ensembl:ENSMUSG00000020734 AllianceGenome:MGI:95822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR2C; GluN2C; NMDAR2C
Summary: Enables NMDA glutamate receptor activity; monoatomic cation channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; neuromuscular process controlling balance; and protein localization to postsynaptic membrane. Located in postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including brain; colon; eye; gallbladder; and genitourinary system. Orthologous to human GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 38.1), frontal lobe adult (RPKM 7.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.8 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115139995..115158123, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115249169..115267297, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression.
Title: NMDAR (2C) deletion in astrocytes relieved LPS-induced neuroinflammation and depression.
Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.
Title: Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.
Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum.
Title: Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum.
Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.
Title: Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.
NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.
Title: NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.
Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.
Title: Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.
Triheteromeric GluN1/GluN2A/GluN2C receptors are the predominant NMADRs in cerebellar granule cells and are co-expressed in those cells.
Title: Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells.
These data reveal a novel mechanism involving plastic modification of synaptically recruited T-type Ca(2+) channels and nucleus Reticularis thalami bursting and indicate a critical role for GluN2C-NMDARs in thalamocortical rhythmogenesis.
Title: Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs.
GluN2C has a very distinct function in the telencephalon compared to its role in other brain regions.
Title: In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.
The results demonstrate that loss of GluN2C subunit leads to cortical excitatory-inhibitory imbalance and abnormal neuronal oscillations associated with neurodevelopmental disorders.
Title: The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Grin2c (e-PCR), detects polymorphism
- UniSTS:143263

L35029 (e-PCR)
- UniSTS:124902

Grin2c (e-PCR), detects polymorphism
- UniSTS:531450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables NMDA glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-gated calcium ion channel activity	IEA Inferred from Electronic Annotation more info
enables glutamate-gated calcium ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within directional locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in excitatory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to postsynaptic membrane	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 2C

Names: GluRepsilon3; N-methyl D-aspartate receptor subtype 2C; glutamate [NMDA] receptor subunit epsilon-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431472.1 → NP_001418401.1 glutamate receptor ionotropic, NMDA 2C precursor

Status: VALIDATED

Source sequence(s)

AL603828

UniProtKB/Swiss-Prot

Q01098

UniProtKB/TrEMBL

A2A6S2
NM_010350.2 → NP_034480.2 glutamate receptor ionotropic, NMDA 2C precursor

See identical proteins and their annotated locations for NP_034480.2

Status: VALIDATED

Source sequence(s)

AL603828, D10694

Consensus CDS

CCDS25624.1

UniProtKB/Swiss-Prot

Q01098

UniProtKB/TrEMBL

A2A6S2

Related

ENSMUSP00000102164.2, ENSMUST00000106554.2

Conserved Domains (3) summary

cd13718
Location:400 → 800

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:837 → 912

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

115139995..115158123 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245576.1 → XP_030101436.1 glutamate receptor ionotropic, NMDA 2C isoform X5

Related

ENSMUSP00000003351.7, ENSMUST00000003351.13

Conserved Domains (3) summary

cd13718
Location:400 → 800

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:837 → 912

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_011248739.1 → XP_011247041.1 glutamate receptor ionotropic, NMDA 2C isoform X4

See identical proteins and their annotated locations for XP_011247041.1

Conserved Domains (3) summary

cd13718
Location:400 → 806

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:843 → 918

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_011248742.4 → XP_011247044.1 glutamate receptor ionotropic, NMDA 2C isoform X4

See identical proteins and their annotated locations for XP_011247044.1

Conserved Domains (3) summary

cd13718
Location:400 → 806

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:843 → 918

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_017314280.2 → XP_017169769.1 glutamate receptor ionotropic, NMDA 2C isoform X4

Conserved Domains (3) summary

cd13718
Location:400 → 806

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:843 → 918

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_011248741.2 → XP_011247043.1 glutamate receptor ionotropic, NMDA 2C isoform X4

See identical proteins and their annotated locations for XP_011247043.1

Conserved Domains (3) summary

cd13718
Location:400 → 806

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:843 → 918

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:28 → 384

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_017314278.2 → XP_017169767.1 glutamate receptor ionotropic, NMDA 2C isoform X1

Conserved Domains (3) summary

cd13718
Location:462 → 868

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:905 → 980

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:90 → 446

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_011248738.4 → XP_011247040.1 glutamate receptor ionotropic, NMDA 2C isoform X2

Conserved Domains (3) summary

cd13718
Location:462 → 867

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:904 → 979

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:90 → 446

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_017314279.3 → XP_017169768.1 glutamate receptor ionotropic, NMDA 2C isoform X3

Conserved Domains (3) summary

cd13718
Location:462 → 862

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:899 → 974

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:90 → 446

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_017314276.3 → XP_017169765.1 glutamate receptor ionotropic, NMDA 2C isoform X1

Conserved Domains (3) summary

cd13718
Location:462 → 868

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:905 → 980

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:90 → 446

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_017314277.3 → XP_017169766.1 glutamate receptor ionotropic, NMDA 2C isoform X1

Conserved Domains (3) summary

cd13718
Location:462 → 868

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10565
Location:905 → 980

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

cd06378
Location:90 → 446

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
XM_006532242.5 → XP_006532305.1 glutamate receptor ionotropic, NMDA 2C isoform X6

Conserved Domains (3) summary

pfam00060
Location:616 → 785

Lig_chan; Ligand-gated ion channel

cd06378
Location:90 → 446

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cl21456
Location:462 → 783

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_011248743.4 → XP_011247045.1 glutamate receptor ionotropic, NMDA 2C isoform X7

Conserved Domains (3) summary

pfam00060
Location:616 → 727

Lig_chan; Ligand-gated ion channel

cd06378
Location:90 → 446

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

cl21456
Location:462 → 605

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily