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    Btg3 BTG anti-proliferation factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 12228, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Btg3provided by MGI
    Official Full Name
    BTG anti-proliferation factor 3provided by MGI
    Primary source
    MGI:MGI:109532
    See related
    Ensembl:ENSMUSG00000022863 AllianceGenome:MGI:109532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ANA; tob5
    Summary
    This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in genital fat pad adult (RPKM 36.7), placenta adult (RPKM 14.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Btg3 in Genome Data Viewer
    Location:
    16 C3.1; 16 45.36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78156748..78174069, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78359860..78377181, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E330011O21 gene Neighboring gene coxsackie virus and adenovirus receptor Neighboring gene predicted gene, 25038 Neighboring gene STARR-positive B cell enhancer ABC_E5553 Neighboring gene STARR-seq mESC enhancer starr_41307 Neighboring gene STARR-seq mESC enhancer starr_41309 Neighboring gene STARR-positive B cell enhancer ABC_E9935 Neighboring gene STARR-seq mESC enhancer starr_41310 Neighboring gene DNA segment, Chr 16, ERATO Doi 472, expressed Neighboring gene RIKEN cDNA 4930478L05 gene Neighboring gene STARR-positive B cell enhancer ABC_E4183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:78560476-78560629 Neighboring gene STARR-positive B cell enhancer mm9_chr16:78564961-78565261

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Yoneda M, et al. Cancer Sci, 2009 Feb. PMID 19068083, Free PMC Article
    2. ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events. Miyai K, et al. J Biol Chem, 2009 Apr 17. PMID 19234306, Free PMC Article
    3. Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation. Cheng YC, et al. Cell Death Dis, 2020 Dec 11. PMID 33311481, Free PMC Article
    4. A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis. Cheng YC, et al. Cell Death Differ, 2024 Aug. PMID 38714880, Free PMC Article
    5. Expression of rat BTG(3) gene, Rbtg3, is regulated by redox changes. Seo MS, et al. Gene, 1999 Nov 15. PMID 10564823

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis.
      Title: A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis.
    2. Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.
      Title: Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.
    3. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
      Title: Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
    4. Results suggest that ANA is a suppressor of ectopic bone formation induced by bone morphogenetic proteins, and this inhibitory ANA activity is a part of the negative feedback regulation of BMP function.
      Title: ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein BTG3
    Names
    B cell translocation gene 3
    BTG family member 3
    abundant in neuroepithelium area protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297747.1 → NP_001284676.1  protein BTG3

      See identical proteins and their annotated locations for NP_001284676.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC130844
      Consensus CDS
      CCDS28277.1
      UniProtKB/Swiss-Prot
      P50615, Q62328
      UniProtKB/TrEMBL
      Q52L83
      Conserved Domains (1) summary
      smart00099
      Location:1 → 108
      btg1; tob/btg1 family

    2. NM_009770.3 → NP_033900.1  protein BTG3

      See identical proteins and their annotated locations for NP_033900.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC130844, AK144415, CK623612
      Consensus CDS
      CCDS28277.1
      UniProtKB/Swiss-Prot
      P50615, Q62328
      UniProtKB/TrEMBL
      Q52L83
      Related
      ENSMUSP00000023570.8, ENSMUST00000023570.14
      Conserved Domains (1) summary
      smart00099
      Location:1 → 108
      btg1; tob/btg1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      78156748..78174069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50615.1 GenPept UniProtKB/Swiss-Prot:P50615

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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