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    Lpcat2b lysophosphatidylcholine acyltransferase 2B [ Mus musculus (house mouse) ]

    Gene ID: 70902, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lpcat2bprovided by MGI
    Official Full Name
    lysophosphatidylcholine acyltransferase 2Bprovided by MGI
    Primary source
    MGI:MGI:1918152
    See related
    Ensembl:ENSMUSG00000033794 AllianceGenome:MGI:1918152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aytl1b; 4921521K07Rik
    Summary
    Predicted to enable lysophosphatidic acid acyltransferase activity. Predicted to be involved in glycerolipid metabolic process and phospholipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in genitourinary system; intestine; and respiratory system. Orthologous to human LPCAT2BP (lysophosphatidylcholine acyltransferase 2b, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 51.6) See more
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    Genomic context

    See Lpcat2b in Genome Data Viewer
    Location:
    5 F; 5 52.23 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107579415..107582905)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107431549..107435039)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 17202 Neighboring gene nuclear encoded rRNA 5S 173 Neighboring gene epoxide hydrolase 4 Neighboring gene STARR-seq mESC enhancer starr_13889 Neighboring gene BTB domain containing 8 Neighboring gene predicted gene, 33885 Neighboring gene LSM12 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity  
    enables calcium ion binding  
    enables lysophosphatidic acid acyltransferase activity  
    enables molecular_function  
    Component Evidence Code Pubs
    is_active_in cellular_component  
    is_active_in endoplasmic reticulum  
    located_in membrane  

    General protein information

    Preferred Names
    lysophosphatidylcholine acyltransferase 2B
    Names
    acyltransferase like 1B
    acyltransferase-like 1-B
    lysophosphatidylcholine acyltransferase 2-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027599.3NP_081875.1  lysophosphatidylcholine acyltransferase 2B

      See identical proteins and their annotated locations for NP_081875.1

      Status: VALIDATED

      Source sequence(s)
      AK029548, AV255931, BB572733, BY714455
      Consensus CDS
      CCDS19502.1
      UniProtKB/Swiss-Prot
      Q9D5U0
      UniProtKB/TrEMBL
      B2RT16
      Related
      ENSMUSP00000127318.2, ENSMUST00000166599.2
      Conserved Domains (5) summary
      cd07991
      Location:111323
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:65307
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      cd00051
      Location:392454
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:392453
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:429487
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107579415..107582905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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