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    Akap17b A kinase anchor protein 17B [ Mus musculus (house mouse) ]

    Gene ID: 338351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akap17bprovided by MGI
    Official Full Name
    A kinase anchor protein 17Bprovided by MGI
    Primary source
    MGI:MGI:2443758
    See related
    Ensembl:ENSMUSG00000059708 AllianceGenome:MGI:2443758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Talia; PRKA17B; Sfrs17b; Srsf17b; AKAP-17B; B230333C21Rik; C230056F04Rik
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in cytosol and nuclear speck. Predicted to be part of spliceosomal complex. Is expressed in several structures, including extraembryonic component; heart; liver; lung; and spleen. Orthologous to several human genes including AKAP17A (A-kinase anchoring protein 17A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.2), frontal lobe adult (RPKM 1.8) and 21 other tissues See more
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    Genomic context

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    See Akap17b in Genome Data Viewer
    Location:
    X A3.3; X 21.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (35871832..35909021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36608173..36645465, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14569 Neighboring gene progesterone receptor membrane component 1 Neighboring gene STARR-seq mESC enhancer starr_46998 Neighboring gene ribosomal protein L7, pseudogene 9 Neighboring gene predicted gene, 57674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale phosphorylation analysis of mouse liver. Villén J, et al. Proc Natl Acad Sci U S A, 2007 Jan 30. PMID 17242355, Free PMC Article
    2. Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. Frankenberg S, et al. BMC Dev Biol, 2007 Feb 15. PMID 17302988, Free PMC Article
    3. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 17B
    Names
    A kinase (PRKA) anchor protein 17B
    protein Talia
    protein kinase A-anchoring protein 17B
    serine/arginine-rich splicing factor 17B
    splicing factor, arginine/serine-rich 17b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081956.2 → NP_001075425.1  A-kinase anchor protein 17B isoform 1

      See identical proteins and their annotated locations for NP_001075425.1

      Status: VALIDATED

      Source sequence(s)
      AL450397
      Consensus CDS
      CCDS40924.1
      UniProtKB/Swiss-Prot
      A2A3V1, B0QZD2, Q0P534, Q8BR01, Q8C6P6
      Related
      ENSMUSP00000052042.7, ENSMUST00000051906.13
      Conserved Domains (1) summary
      cd12264
      Location:143 → 262
      RRM_AKAP17A; RNA recognition motif found in A-kinase anchor protein 17A (AKAP-17A) and similar proteins

    2. NM_001419768.1 → NP_001406697.1  A-kinase anchor protein 17B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL450397
      UniProtKB/Swiss-Prot
      A2A3V1, B0QZD2, Q0P534, Q8BR01, Q8C6P6

    3. NM_001419769.1 → NP_001406698.1  A-kinase anchor protein 17B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL450397

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      35871832..35909021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A3V1.2 GenPept UniProtKB/Swiss-Prot:A2A3V1

    Gene LinkOut

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