Rgma repulsive guidance molecule family member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgmaprovided by MGI
Official Full Name: repulsive guidance molecule family member Aprovided by MGI
Primary source: MGI:MGI:2679262
See related: Ensembl:ENSMUSG00000070509 AllianceGenome:MGI:2679262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C230063O06
Summary: Enables coreceptor activity and signaling receptor binding activity. Acts upstream of or within several processes, including BMP signaling pathway; nervous system development; and positive regulation of membrane protein ectodomain proteolysis. Located in cell surface. Is expressed in several structures, including future brain; gut; nervous system; sensory organ; and trunk somite. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 24.7), ovary adult (RPKM 23.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D1; 7 41.85 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (73025268..73069647)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (73375520..73419899)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of RGMA improves ischemic stroke via Reprogramming of Neuronal Metabolism.
Title: Knockdown of RGMA improves ischemic stroke via Reprogramming of Neuronal Metabolism.
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
Title: RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro.
Title: RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro.
RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells.
Title: RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells.
Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer.
Title: Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer.
RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway.
Title: RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway.
Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.
Title: Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.
Inhibiting Rgma suppresses secondary progression in a mouse model of multiple sclerosis.
Title: Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis.
After chronic morphine injection, Rgma was upregulated in C57BL/6J striatum.
Title: Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.
Study focused on the RGMa and RGMb expression in cerebral cortex and hippocampus of newborn mice with maternal lead exposure. RGMa and RGMb expression in hippocampus were upregulated in lead exposed groups, and the RGMa and RGMb expression in cerebral cortex were also higher.
Title: Effects of maternal lead exposure on RGMa and RGMb expression in the hippocampus and cerebral cortex of mouse pups.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rgma (e-PCR), detects polymorphism
- UniSTS:508017

GDB:182516 (e-PCR)
- UniSTS:155384

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables coreceptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferrin receptor binding	IEA Inferred from Electronic Annotation more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: repulsive guidance molecule A

Names: RGM domain family, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177740.5 → NP_808408.2 repulsive guidance molecule A precursor

See identical proteins and their annotated locations for NP_808408.2

Status: VALIDATED

Source sequence(s)

BC059072

Consensus CDS

CCDS21362.2

UniProtKB/Swiss-Prot

Q6PCX7, Q7TQ34, Q8CIH6

Related

ENSMUSP00000091870.6, ENSMUST00000094312.12

Conserved Domains (2) summary

pfam06534
Location:227 → 410

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:48 → 222

RGM_N; Repulsive guidance molecule (RGM) N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

73025268..73069647

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540902.2 → XP_006540965.1 repulsive guidance molecule A isoform X1

See identical proteins and their annotated locations for XP_006540965.1

UniProtKB/Swiss-Prot

Q6PCX7

Related

ENSMUSP00000145758.2, ENSMUST00000139780.3

Conserved Domains (2) summary

pfam06534
Location:211 → 389

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:32 → 206

RGM_N; Repulsive guidance molecule (RGM) N-terminus