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    Pon1 paraoxonase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pon1provided by MGI
    Official Full Name
    paraoxonase 1provided by MGI
    Primary source
    MGI:MGI:103295
    See related
    Ensembl:ENSMUSG00000002588 AllianceGenome:MGI:103295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pon
    Summary
    Enables arylesterase activity. Acts upstream of or within cholesterol metabolic process and response to toxic substance. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 147.4), liver E18 (RPKM 50.7) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Pon1 in Genome Data Viewer
    Location:
    6 A1; 6 1.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5168101..5193824, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5168090..5193987, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene predicted gene, 52886 Neighboring gene STARR-seq mESC enhancer starr_15032 Neighboring gene predicted gene, 46949 Neighboring gene STARR-seq mESC enhancer starr_15033 Neighboring gene paraoxonase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3642 Neighboring gene paraoxonase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia. Ng DS, et al. Cardiovasc Pathol, 2008 Jul-Aug. PMID 18402813
    2. Paraoxonase-1 deficiency is associated with severe liver steatosis in mice fed a high-fat high-cholesterol diet: a metabolomic approach. García-Heredia A, et al. J Proteome Res, 2013 Apr 5. PMID 23448543
    3. An aqueous extract of Murraya koenigii leaves induces paraoxonase 1 activity in streptozotocin induced diabetic mice. Saha A, et al. Food Funct, 2013 Feb 26. PMID 23207871
    4. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1. Borowczyk K, et al. J Alzheimers Dis, 2012. PMID 22406444, Free PMC Article
    5. The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates β-cell insulin release. Koren-Gluzer M, et al. Atherosclerosis, 2011 Dec. PMID 21862013

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice.
      Title: Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice.
    2. Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet.
      Title: Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet.
    3. Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.
      Title: Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.
    4. Ccl2 gene ablation protects LDL receptor and PON1 double deficient mice from liver injury, oxidative stress and inflammation.
      Title: Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation.
    5. Study shows that PON1 can significantly relieve airway inflammation and airway remolding in asthma mice, and inhibit the secretion of LPS induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. These results suggest that PON1 may be involved in airway inflammation and remodeling in asthma.
      Title: Influences of PON1 on airway inflammation and remodeling in bronchial asthma.
    6. PON1 overexpression protects against AAA progression by reducing oxidative stress, apoptosis and inflammation
      Title: Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression.
    7. Paraoxonase 1 (PON1) influence circadian gene expression and period length
      Title: Paraoxonase 1 (PON1) and pomegranate influence circadian gene expression and period length.
    8. results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL, owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.
      Title: Hyperhomocysteinemia: a missing link to dysfunctional HDL via paraoxanase-1.
    9. Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.
      Title: Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues.
    10. 5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.
      Title: 5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-L-homoserine-lactone lactonohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-L-homoserine-lactone lactonohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aryldialkylphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryldialkylphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aryldialkylphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables arylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables high-density lipoprotein particle binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood circulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in carboxylic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cholesterol metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lactone catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactone catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organophosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organophosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol efflux IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to fluoride ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to toxic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spherical high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spherical high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serum paraoxonase/arylesterase 1
    Names
    A-esterase 1
    PON 1
    aromatic esterase 1
    serum aryldialkylphosphatase 1
    NP_001397188.1
    NP_001397189.1
    NP_001397190.1
    NP_035264.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410259.1 → NP_001397188.1  serum paraoxonase/arylesterase 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC074225

    2. NM_001410260.1 → NP_001397189.1  serum paraoxonase/arylesterase 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC074225
      UniProtKB/TrEMBL
      H3BK03
      Related
      ENSMUSP00000135195.3, ENSMUST00000177159.9

    3. NM_001410261.1 → NP_001397190.1  serum paraoxonase/arylesterase 1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC074225
      UniProtKB/TrEMBL
      H3BK03

    4. NM_011134.4 → NP_035264.2  serum paraoxonase/arylesterase 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_035264.2

      Status: VALIDATED

      Source sequence(s)
      AC074225
      Consensus CDS
      CCDS19898.1
      UniProtKB/Swiss-Prot
      P52430, Q91X30
      Related
      ENSMUSP00000002663.6, ENSMUST00000002663.12
      Conserved Domains (1) summary
      pfam01731
      Location:168 → 253
      Arylesterase; Arylesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      5168101..5193824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52430.2 GenPept UniProtKB/Swiss-Prot:P52430

    Gene LinkOut

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