Obox1 oocyte specific homeobox 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Obox1provided by MGI
Official Full Name: oocyte specific homeobox 1provided by MGI
Primary source: MGI:MGI:1918718
See related: Ensembl:ENSMUSG00000054310 AllianceGenome:MGI:1918718
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 7420700M11Rik
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in maternal-to-zygotic transition of gene expression and stem cell population maintenance. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system; inner ear; and urinary system. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward ovary adult (RPKM 2.7) See more
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Genomic context

Location:: 7 A2; 7 8.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (15281182..15290771)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (15547257..15556846)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Obox1 serves as a strong activator for somatic cell reprogramming through promoting the mesenchymal-to-epithelial transition and mitigating cell hyperproliferation.
Title: Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation.

Submit: New GeneRIF Correction

General gene information

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Markers

Obox3 (e-PCR), detects polymorphism
- UniSTS:547851

AU024152 (e-PCR)
- UniSTS:179519

Obox1 (e-PCR), detects polymorphism
- UniSTS:239182

C87544 (e-PCR)
- UniSTS:208067

RH127151 (e-PCR)
- UniSTS:208069

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in maternal-to-zygotic transition of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oocyte-specific homeobox protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027802.2 → NP_082078.1 oocyte-specific homeobox protein 1

See identical proteins and their annotated locations for NP_082078.1

Status: PROVISIONAL

Source sequence(s)

AC189859

Consensus CDS

CCDS20837.1

UniProtKB/Swiss-Prot

G3UX03, Q9D350

UniProtKB/TrEMBL

A0AA74J9U6

Related

ENSMUSP00000067691.9, ENSMUST00000067288.15

Conserved Domains (1) summary

cd00086
Location:95 → 153

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.