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    Acox3 acyl-Coenzyme A oxidase 3, pristanoyl [ Mus musculus (house mouse) ]

    Gene ID: 80911, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Acox3provided by MGI
    Official Full Name
    acyl-Coenzyme A oxidase 3, pristanoylprovided by MGI
    Primary source
    MGI:MGI:1933156
    See related
    Ensembl:ENSMUSG00000029098 AllianceGenome:MGI:1933156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCOX; EST-s59
    Summary
    Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to act upstream of or within fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including brain; colon; genitourinary system; heart; and lung. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 39.5), kidney adult (RPKM 13.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acox3 in Genome Data Viewer
    Location:
    5 B3; 5 18.32 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35740293..35772397)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35582981..35614208)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12857 Neighboring gene carboxypeptidase Z Neighboring gene polo like kinase, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_12858 Neighboring gene tRNA methyltransferase 44 Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene HtrA serine peptidase 3 Neighboring gene STARR-seq mESC enhancer starr_12860 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene predicted gene, 31888

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal beta-oxidation enzyme gene expression in the developing mouse brain. Knoll A, et al. Neurosci Lett, 2000 May 19. PMID 10806321
    2. Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing. Biase FH, et al. Genome Res, 2014 Nov. PMID 25096407, Free PMC Article
    3. The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Yubero P, et al. Endocrinology, 2004 Sep. PMID 15178647
    4. Spermatogonia-dependent expression of testicular genes in mice. Tanaka K, et al. Dev Biol, 2002 Jun 15. PMID 12051830
    5. Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration. Li X, et al. Life Sci, 2023 May 1. PMID 36878279

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pristanoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pristanoyl-CoA oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pristanoyl-CoA oxidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal acyl-coenzyme A oxidase 3
    Names
    BRCACox
    branched-chain acyl-CoA oxidase
    pristanoyl-CoA oxidase
    NP_001343947.1
    NP_001343948.1
    NP_001343949.1
    NP_001412726.1
    NP_109646.2
    XP_006504259.1
    XP_006504260.1
    XP_006504262.1
    XP_006504263.1
    XP_011239103.1
    XP_017176668.1
    XP_036021519.1
    XP_036021520.1
    XP_036021521.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357018.2 → NP_001343947.1  peroxisomal acyl-coenzyme A oxidase 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 5 all encode the same isoform (a).
      Source sequence(s)
      AC122871
      Consensus CDS
      CCDS19232.1
      UniProtKB/Swiss-Prot
      Q7TPP6, Q80UQ0, Q9EPL9
      UniProtKB/TrEMBL
      E9Q296
      Related
      ENSMUSP00000109875.2, ENSMUST00000114237.8
      Conserved Domains (1) summary
      cd01150
      Location:19 → 672
      AXO; Peroxisomal acyl-CoA oxidase

    2. NM_001357019.2 → NP_001343948.1  peroxisomal acyl-coenzyme A oxidase 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 5 all encode the same isoform (a).
      Source sequence(s)
      AC122871
      Consensus CDS
      CCDS19232.1
      UniProtKB/Swiss-Prot
      Q7TPP6, Q80UQ0, Q9EPL9
      UniProtKB/TrEMBL
      E9Q296
      Conserved Domains (1) summary
      cd01150
      Location:19 → 672
      AXO; Peroxisomal acyl-CoA oxidase

    3. NM_001357020.2 → NP_001343949.1  peroxisomal acyl-coenzyme A oxidase 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC122871
      Consensus CDS
      CCDS89913.1
      UniProtKB/TrEMBL
      E9Q296, Q8C178
      Related
      ENSMUSP00000067178.6, ENSMUST00000068563.12
      Conserved Domains (1) summary
      cd01150
      Location:19 → 662
      AXO; Peroxisomal acyl-CoA oxidase

    4. NM_001425797.1 → NP_001412726.1  peroxisomal acyl-coenzyme A oxidase 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes the longer isoform (a). Variants 1, 2, 3 and 5 all encode the same isoform (a).
      Source sequence(s)
      AC122871
      UniProtKB/Swiss-Prot
      Q7TPP6, Q80UQ0, Q9EPL9
      UniProtKB/TrEMBL
      E9Q296

    5. NM_030721.4 → NP_109646.2  peroxisomal acyl-coenzyme A oxidase 3 isoform a

      See identical proteins and their annotated locations for NP_109646.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 3 and 5 all encode the same isoform (a).
      Source sequence(s)
      AC122871
      Consensus CDS
      CCDS19232.1
      UniProtKB/Swiss-Prot
      Q7TPP6, Q80UQ0, Q9EPL9
      UniProtKB/TrEMBL
      E9Q296
      Related
      ENSMUSP00000063412.8, ENSMUST00000068947.14
      Conserved Domains (1) summary
      cd01150
      Location:19 → 672
      AXO; Peroxisomal acyl-CoA oxidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      35740293..35772397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504199.5 → XP_006504262.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X3

      See identical proteins and their annotated locations for XP_006504262.1

      UniProtKB/TrEMBL
      E9Q296, Q3TAW3
      Related
      ENSMUSP00000144499.2, ENSMUST00000202266.4
      Conserved Domains (1) summary
      cd01150
      Location:19 → 662
      AXO; Peroxisomal acyl-CoA oxidase

    2. XM_006504200.5 → XP_006504263.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X4

      UniProtKB/TrEMBL
      E9Q296
      Conserved Domains (1) summary
      cd01150
      Location:19 → 661
      AXO; Peroxisomal acyl-CoA oxidase

    3. XM_017321179.3 → XP_017176668.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

      UniProtKB/TrEMBL
      E9Q296
      Conserved Domains (1) summary
      cd01150
      Location:19 → 663
      AXO; Peroxisomal acyl-CoA oxidase

    4. XM_006504197.5 → XP_006504260.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

      See identical proteins and their annotated locations for XP_006504260.1

      UniProtKB/TrEMBL
      E9Q296
      Conserved Domains (1) summary
      cd01150
      Location:19 → 663
      AXO; Peroxisomal acyl-CoA oxidase

    5. XM_011240801.4 → XP_011239103.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

      See identical proteins and their annotated locations for XP_011239103.1

      UniProtKB/TrEMBL
      E9Q296
      Conserved Domains (1) summary
      cd01150
      Location:19 → 663
      AXO; Peroxisomal acyl-CoA oxidase

    6. XM_006504196.5 → XP_006504259.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

      See identical proteins and their annotated locations for XP_006504259.1

      UniProtKB/TrEMBL
      E9Q296
      Conserved Domains (1) summary
      cd01150
      Location:19 → 663
      AXO; Peroxisomal acyl-CoA oxidase

    7. XM_036165628.1 → XP_036021521.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X6

      Conserved Domains (1) summary
      cl09933
      Location:1 → 359
      ACAD; Acyl-CoA dehydrogenase

    8. XM_036165627.1 → XP_036021520.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X5

      Conserved Domains (1) summary
      cl09933
      Location:1 → 350
      ACAD; Acyl-CoA dehydrogenase

    9. XM_036165626.1 → XP_036021519.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X5

      Conserved Domains (1) summary
      cl09933
      Location:1 → 350
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPL9.2 GenPept UniProtKB/Swiss-Prot:Q9EPL9

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