Zpld1 zona pellucida like domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zpld1provided by MGI
Official Full Name: zona pellucida like domain containing 1provided by MGI
Primary source: MGI:MGI:2443415
See related: Ensembl:ENSMUSG00000064310 AllianceGenome:MGI:2443415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9430016A21Rik
Summary: Acts upstream of or within vestibular reflex. Predicted to be located in cytoplasmic vesicle membrane and extracellular region. Predicted to be active in cell surface and extracellular space. Is expressed in axial skeleton; cochlea; femur; fibula; and tibia. Orthologous to human ZPLD1 (zona pellucida like domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 16 C1.1; 16 33.65 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (55045538..55142403, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (55224125..55322025, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions.
Title: Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Spontaneous (2) 1 citation

General gene information

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Markers

D16Mit221 (e-PCR), detects polymorphism
- UniSTS:127856

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within vestibular reflex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zona pellucida-like domain-containing protein 1

Names: ZP domain-containing protein 1; cupulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417872.1 → NP_001404801.1 zona pellucida-like domain-containing protein 1 precursor

Status: VALIDATED

Source sequence(s)

AC155271

UniProtKB/Swiss-Prot

Q14BA1, Q8BGZ8
NM_178720.5 → NP_848835.1 zona pellucida-like domain-containing protein 1 precursor

See identical proteins and their annotated locations for NP_848835.1

Status: VALIDATED

Source sequence(s)

AC155271

Consensus CDS

CCDS28215.1

UniProtKB/Swiss-Prot

Q14BA1, Q8BGZ8

Related

ENSMUSP00000049012.4, ENSMUST00000036412.4

Conserved Domains (1) summary

pfam00100
Location:44 → 305

Zona_pellucida; Zona pellucida-like domain