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    Glce glucuronyl C5-epimerase [ Mus musculus (house mouse) ]

    Gene ID: 93683, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glceprovided by MGI
    Official Full Name
    glucuronyl C5-epimeraseprovided by MGI
    Primary source
    MGI:MGI:2136405
    See related
    Ensembl:ENSMUSG00000032252 AllianceGenome:MGI:2136405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsepi; 1110017N23Rik; C130034A12Rik
    Summary
    Enables heparosan-N-sulfate-glucuronate 5-epimerase activity. Involved in heparan sulfate proteoglycan biosynthetic process and heparin biosynthetic process. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in cerebrovascular disease and hypertension. Orthologous to human GLCE (glucuronic acid epimerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.6), cerebellum adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Glce in Genome Data Viewer
    Location:
    9 B; 9 33.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (61964526..62029891, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62057244..62122609, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 23 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61794519-61794820 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61795876-61796177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:61808677-61808878 Neighboring gene STARR-positive B cell enhancer ABC_E5075 Neighboring gene progestin and adipoQ receptor family member V Neighboring gene predicted gene, 35152 Neighboring gene STARR-positive B cell enhancer ABC_E570 Neighboring gene STARR-seq mESC enhancer starr_24364 Neighboring gene microRNA 5133 Neighboring gene predicted gene, 39351 Neighboring gene predicted gene, 35227

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    D-glucuronyl C5-epimerase
    Names
    heparan sulfate C5-epimerase
    heparan sulfate-glucuronic acid C5-epimerase
    heparin sulfate C5-epimerase
    heparin/heparan sulfate:glucuronic acid C5-epimerase
    heparosan-N-sulfate-glucuronate 5-epimerase
    NP_001355233.1
    NP_201577.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368304.1NP_001355233.1  D-glucuronyl C5-epimerase

      Status: VALIDATED

      Source sequence(s)
      AC123610
      Consensus CDS
      CCDS23262.1
      UniProtKB/Swiss-Prot
      Q505E6, Q99MM0, Q9EPS3
      Related
      ENSMUSP00000034785.8, ENSMUST00000034785.8
    2. NM_033320.5NP_201577.3  D-glucuronyl C5-epimerase

      See identical proteins and their annotated locations for NP_201577.3

      Status: VALIDATED

      Source sequence(s)
      AC123610
      Consensus CDS
      CCDS23262.1
      UniProtKB/Swiss-Prot
      Q505E6, Q99MM0, Q9EPS3
      Related
      ENSMUSP00000139949.2, ENSMUST00000185675.7
      Conserved Domains (1) summary
      pfam06662
      Location:417608
      C5-epim_C; D-glucuronyl C5-epimerase C-terminus

    RNA

    1. NR_160774.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123610

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      61964526..62029891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)