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    FLASH FLICE-associated huge protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FLASHprovided by FlyBase
    Official Full Name
    FLICE-associated huge proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033806
    Locus tag
    Dmel_CG4616
    See related
    AllianceGenome:FB:FBgn0033806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4616; dFLASH; Dmel\CG4616
    Summary
    Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in histone locus body. Part of histone pre-mRNA 3'end processing complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FLASH in Genome Data Viewer
    Location:
    49F8-49F9; 2-68 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13206745..13210469)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9094250..9097974)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Valyl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene Origin recognition complex subunit 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene aquaporin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A region of SLBP outside the mRNA-processing domain is essential for deposition of histone mRNA into the Drosophila egg. Potter-Birriel JM, et al. J Cell Sci, 2021 Feb 11. PMID 33408246, Free PMC Article
    2. Superresolution light microscopy of the Drosophila histone locus body reveals a core-shell organization associated with expression of replication-dependent histone genes. Kemp JP Jr, et al. Mol Biol Cell, 2021 Apr 19. PMID 33788585, Free PMC Article
    3. Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila. Burch BD, et al. RNA, 2011 Jun. PMID 21525146, Free PMC Article
    4. A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs. Salzler HR, et al. Dev Cell, 2013 Mar 25. PMID 23537633, Free PMC Article
    5. Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body. Terzo EA, et al. Mol Biol Cell, 2015 Apr 15. PMID 25694448, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila U7 snRNP is associated with FLASH and a complex of polyadenylation factors that resembles the mammalian histone pre-mRNA cleavage complex.
      Title: 3'-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors.
    2. Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila
      Title: Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila.
    3. Drosophila FLASH localizes to histone locus bodies, and its depletion from fly cells inhibits U7-dependent processing, resulting in polyadenylation of histone mRNAs.
      Title: FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in histone locus body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of histone pre-mRNA 3'end processing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FLICE-associated huge protein
    Names
    CG4616-PA
    CG4616-PB
    FLASH ortholog
    FLASH-PA
    FLASH-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13206745..13210469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206106.3 → NP_995828.1  FLICE-associated huge protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0L8, Q8SZS8
      Conserved Domains (2) summary
      pfam08648
      Location:258 → 342
      DUF1777; Protein of unknown function (DUF1777)
      pfam16046
      Location:266 → 397
      FAM76; FAM76 protein

    2. NM_137001.4 → NP_610845.1  FLICE-associated huge protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0L8, Q8SZS8
      Related
      FBpp0086849
      Conserved Domains (2) summary
      pfam08648
      Location:258 → 342
      DUF1777; Protein of unknown function (DUF1777)
      pfam16046
      Location:266 → 397
      FAM76; FAM76 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0L8 Q7K0L8
    Q8SZS8 Q8SZS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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