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    Cog8 Component of oligomeric golgi complex 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cog8provided by FlyBase
    Official Full Name
    Component of oligomeric golgi complex 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0287204
    Locus tag
    Dmel_CG6488
    See related
    AllianceGenome:FB:FBgn0287204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6488; COG8; Dmel\CG6488
    Summary
    Predicted to be involved in intra-Golgi vesicle-mediated transport. Part of Golgi transport complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIh. Orthologous to human COG8 (component of oligomeric golgi complex 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Cog8 in Genome Data Viewer
    Location:
    32F2-32F2; 2-44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11496804..11498948, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11496804..11498948, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46454 Neighboring gene uncharacterized protein Neighboring gene spalt-adjacent Neighboring gene spatzle 4 Neighboring gene Discs large 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content. Hartwig C, et al. J Neurosci, 2021 Jan 13. PMID 33208468, Free PMC Article
    2. Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith RD, et al. Carbohydr Res, 2008 Aug 11. PMID 18353293, Free PMC Article
    3. A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population. Lange JD, et al. Mol Biol Evol, 2022 Feb 3. PMID 34971382, Free PMC Article
    4. The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle. Spletter ML, et al. EMBO Rep, 2015 Feb. PMID 25532219, Free PMC Article
    5. Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. Dottorini T, et al. BMC Bioinformatics, 2011 Jan 26. PMID 21269436, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Golgi transport complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    component of oligomeric golgi complex 8
    Names
    CG6488-PA
    Cog8-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11496804..11498948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135659.3 → NP_609503.2  component of oligomeric golgi complex 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609503.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNB2, Q8T9C7, Q9VKH0
      Related
      FBpp0079833
      Conserved Domains (1) summary
      pfam04124
      Location:37 → 379
      Dor1; Dor1-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKH0.1 Q9VKH0

    Gene LinkOut

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