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    spirit Serine Protease Immune Response Integrator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spiritprovided by FlyBase
    Official Full Name
    Serine Protease Immune Response Integratorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030051
    Locus tag
    Dmel_CG2056
    See related
    AllianceGenome:FB:FBgn0030051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP33; CG2056; cSP33; Dmel\CG2056; SP33; Spirit
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in Toll receptor ligand protein activation cascade and defense response to other organism. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spirit in Genome Data Viewer
    Location:
    7F5-7F5; 1-23 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8571099..8573593, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8465132..8467626, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Topoisomerase related function 4-1 Neighboring gene antisense RNA:CR46195 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of five immunity-related genes reveals different levels of adaptive evolution in the virilis and melanogaster groups of Drosophila. Morales-Hojas R, et al. Heredity (Edinb), 2009 Jun. PMID 19223926
    2. KDM5 interacts with Foxo to modulate cellular levels of oxidative stress. Liu X, et al. PLoS Genet, 2014 Oct. PMID 25329053, Free PMC Article
    3. Sex-dependent and sex-independent regulatory systems of size variation in natural populations. Okada H, et al. Mol Syst Biol, 2019 Nov. PMID 31777173, Free PMC Article
    4. Selective sweeps in a 2-locus model for sex-ratio meiotic drive in Drosophila simulans. Derome N, et al. Mol Biol Evol, 2008 Feb. PMID 18071199
    5. Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC. Kurata S. Int Immunol, 2010 Mar. PMID 20089584, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine protease immune response integrator
    Names
    CG2056-PA
    CG2056-PB
    CG2056-PC
    CG2056-PD
    response integrator
    serine protease immune
    spirit
    spirit-PA
    spirit-PB
    spirit-PC
    spirit-PD
    NP_001162707.1
    NP_001259342.1
    NP_572492.1
    NP_727276.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8571099..8573593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169236.2 → NP_001162707.1  serine protease immune response integrator, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V9V4, Q7K3Y1
      Conserved Domains (3) summary
      smart00680
      Location:51 → 98
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:132 → 361
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:132 → 364
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_167161.2 → NP_727276.1  serine protease immune response integrator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V9V4, Q7K3Y1
      Related
      FBpp0071174
      Conserved Domains (3) summary
      smart00680
      Location:51 → 98
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:132 → 361
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:132 → 364
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_001272413.1 → NP_001259342.1  serine protease immune response integrator, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V9V4, Q7K3Y1
      Conserved Domains (3) summary
      smart00680
      Location:51 → 98
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:132 → 361
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:132 → 364
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. NM_132264.3 → NP_572492.1  serine protease immune response integrator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V9V4, Q7K3Y1
      Related
      FBpp0071175
      Conserved Domains (3) summary
      smart00680
      Location:51 → 98
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:132 → 361
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:132 → 364
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3Y1 Q7K3Y1

    Gene LinkOut

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