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    CG10859 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10859provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032520
    Locus tag
    Dmel_CG10859
    See related
    AllianceGenome:FB:FBgn0032520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10859
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be part of outer dynein arm. Is expressed in adult head and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10859 in Genome Data Viewer
    Location:
    34B10-34B10; 2-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13396392..13398664, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13396392..13398664, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L24 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44600 Neighboring gene uncharacterized protein Neighboring gene Vitelline membrane 34Ca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex. Boylan K, et al. Mol Biol Cell, 2000 Nov. PMID 11071907, Free PMC Article
    2. Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins. Kim JC, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21933960, Free PMC Article
    3. Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. Karak S, et al. Sci Rep, 2015 Nov 26. PMID 26608786, Free PMC Article
    4. Dyneins across eukaryotes: a comparative genomic analysis. Wickstead B, et al. Traffic, 2007 Dec. PMID 17897317, Free PMC Article
    5. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of outer dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10859-PA
    CG10859-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13396392..13398664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135807.3 → NP_609651.1  uncharacterized protein Dmel_CG10859, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJY4
      Related
      FBpp0080100
      Conserved Domains (3) summary
      COG2319
      Location:261 → 512
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:284 → 332
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:279 → 492
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001298969.1 → NP_001285898.1  uncharacterized protein Dmel_CG10859, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJY4
      Conserved Domains (3) summary
      COG2319
      Location:261 → 512
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:284 → 332
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:279 → 492
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJY4 Q9VJY4

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