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    mia meiosis I arrest [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    miaprovided by FlyBase
    Official Full Name
    meiosis I arrestprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014342
    Locus tag
    Dmel_CG10390
    See related
    AllianceGenome:FB:FBgn0014342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10390; Dmel\CG10390; dmTAF6b; dTAF6L; dTAF[[II]]60; dTAF[[II]]60-2; Mia; ms(3)570; TAF; Taf60-2; TAF60-2; taf6L; Taf6L; TAF6L; TAF[[II]]; TAF[[II]]60-2; TFIID
    Summary
    Predicted to enable transcription coactivator activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in male meiosis I; regulation of gene expression; and spermatid differentiation. Located in male germ cell nucleus and nucleolus. Is expressed in spermatocyte and testis. Orthologous to human TAF6 (TATA-box binding protein associated factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mia in Genome Data Viewer
    Location:
    83B1-83B1; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5548115..5551168, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1373837..1376890, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene NMDA receptor 1 Neighboring gene Inositol 1,4,5,-trisphosphate receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol 4-kinase II alpha Neighboring gene Protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene Snm1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Male-specific IDGF, a novel gene encoding a membrane-bound extracellular signaling molecule expressed exclusively in testis of Drosophila melanogaster. Matsushita T, et al. J Biol Chem, 2000 Nov 24. PMID 10967093
    2. Approaches to defining the ancestral eukaryotic protein complexome. Ceulemans H, et al. Bioessays, 2006 Mar. PMID 16479579
    3. Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation. Goodrich JA, et al. Nat Rev Genet, 2010 Aug. PMID 20628347, Free PMC Article
    4. VCP promotes tTAF-target gene expression and spermatocyte differentiation by downregulating mono-ubiquitylated H2A. Butsch TJ, et al. Development, 2023 Jul 15. PMID 37401420, Free PMC Article
    5. Transcription of meiotic cell cycle and terminal differentiation genes depends on a conserved chromatin associated protein, whose nuclear localisation is regulated. White-Cooper H, et al. Development, 2000 Dec. PMID 11076766

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiosis I arrest
    Names
    CG10390-PA
    CG10390-PB
    CG10390-PC
    TAF6-like
    TBP-associated factor 6-like
    TBP-associated factor 60kD-2
    mia-PA
    mia-PB
    mia-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5548115..5551168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141290.6 → NP_649547.3  meiosis I arrest, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649547.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VND0, R4I0S2
      Related
      FBpp0088355
      Conserved Domains (2) summary
      cd08050
      Location:33 → 352
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      COG5095
      Location:40 → 422
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]

    2. NM_001300252.1 → NP_001287181.1  meiosis I arrest, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287181.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VND0, R4I0S2
      Conserved Domains (2) summary
      cd08050
      Location:33 → 352
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      COG5095
      Location:40 → 422
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]

    3. NM_001144538.2 → NP_001138010.1  meiosis I arrest, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VND0, R4I0S2
      Conserved Domains (2) summary
      cd08050
      Location:33 → 352
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      COG5095
      Location:40 → 422
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5UEC4 Q5UEC4
    Q8IG94 Q8IG94
    Q95T18 Q95T18
    Q9VND0 Q9VND0

    Gene LinkOut

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