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    ais aramis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aisprovided by FlyBase
    Official Full Name
    aramisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036754
    Locus tag
    Dmel_CG5589
    See related
    AllianceGenome:FB:FBgn0036754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aramis; cg5589; CG5589; Dmel\CG5589; DmRH17; Rok1
    Summary
    Enables rRNA binding activity. Involved in rRNA processing. Located in cytosol. Is active in nucleolus. Orthologous to human DDX52 (DExD-box helicase 52). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ais in Genome Data Viewer
    Location:
    75A2-75A2; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17802490..17804715, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17795590..17797815, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nucleobindin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DEAD-Box Protein Rok1 Coordinates Ribosomal RNA Processing in Association with Rrp5 in Drosophila. Chen J, et al. Int J Mol Sci, 2022 May 19. PMID 35628496, Free PMC Article
    2. Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster. Salces-Ortiz J, et al. Philos Trans R Soc Lond B Biol Sci, 2020 Mar 30. PMID 32075557, Free PMC Article
    3. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Martin ET, et al. Dev Cell, 2022 Apr 11. PMID 35413237, Free PMC Article
    4. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. Rech GE, et al. PLoS Genet, 2019 Feb. PMID 30753202, Free PMC Article
    5. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA helicase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aramis
    Names
    CG5589-PA
    ais-PA
    NP_649009.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17802490..17804715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140752.3 → NP_649009.1  aramis [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649009.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVK8
      UniProtKB/TrEMBL
      H9ZYP2
      Related
      FBpp0074936
      Conserved Domains (3) summary
      COG0513
      Location:87 → 594
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:349 → 469
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:123 → 329
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVK8.1 Q9VVK8

    Gene LinkOut

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