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    Vha16-1 Vacuolar H[+] ATPase 16kD subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44307, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Vha16-1provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 16kD subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0262736
    Locus tag
    Dmel_CG3161
    See related
    AllianceGenome:FB:FBgn0262736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATP6V0C; BcDNA:SD02875; CG3161; Dmel\CG3161; DucC; EP2372; MRE15; v-ATPase; V-ATPase; Vha1; vha16; Vha16; vha16-1; Vhac
    Summary
    Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in fusome. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including anterior-posterior subdivision of organism; female germline cell; follicle cell; ganglia; and somatic muscle cell. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vha16-1 in Genome Data Viewer
    Location:
    42B2-42B2; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6625242..6633090, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2512747..2520595, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene jing Neighboring gene stable intronic sequence RNA CR46361 Neighboring gene uncharacterized protein Neighboring gene Trap1 Neighboring gene Brahma associated protein 170kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of a cDNA from Drosophila coding for the 16 kD proteolipid component of the vacuolar H(+)-ATPase. Meagher L, et al. Nucleic Acids Res, 1990 Nov 25. PMID 2147478, Free PMC Article
    2. Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice. Lin WS, et al. PLoS One, 2015. PMID 26436771, Free PMC Article
    3. Microinjected antisera against ductin affect gastrulation in Drosophila melanogaster. Bohrmann J, et al. Int J Dev Biol, 1998 Jul. PMID 9712526
    4. Tissue-specific distribution and variation of the channel-forming protein ductin during development of Drosophila melanogaster. Bohrmann J, et al. Int J Dev Biol, 2000 Dec. PMID 11206329
    5. Evidence that the 16 kDa proteolipid (subunit c) of the vacuolar H(+)-ATPase and ductin from gap junctions are the same polypeptide in Drosophila and Manduca: molecular cloning of the Vha16k gene from Drosophila. Finbow ME, et al. J Cell Sci, 1994 Jul. PMID 7983150

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lysosomal-associated functions regulated by the TFEB-V-ATPase axis might play a conserved role in shaping cell fate.
      Title: Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of plasma membrane proton-transporting V-type ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+] ATPase 16kD subunit 1
    Names
    CG3161-PA
    CG3161-PB
    CG3161-PC
    CG3161-PD
    Vha16-1-PA
    Vha16-1-PB
    Vha16-1-PC
    Vha16-1-PD
    c subunit
    ductin
    ductin subunit C
    ductin, vacuolar H(+)-ATPase subunit C proteolipid
    mRNA-like ncRNA in embryogenesis 15
    vacuolar H[+] ATPase 16kD subunit
    vacuolar H[+] ATPase subunit 16-1
    vacuolar H[+]-ATPase c subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6625242..6633090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057453.5 → NP_476801.1  vacuolar H[+] ATPase 16kD subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476801.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ55, P23380, Q0E9N6, Q53XD4, Q9V9D2
      Related
      FBpp0085483
      Conserved Domains (2) summary
      TIGR01100
      Location:15 → 122
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:90 → 157
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

    2. NM_165474.3 → NP_724474.1  vacuolar H[+] ATPase 16kD subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ55, P23380, Q0E9N6, Q53XD4, Q9V9D2
      Related
      FBpp0085484
      Conserved Domains (2) summary
      TIGR01100
      Location:15 → 122
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:90 → 157
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

    3. NM_165476.3 → NP_724476.1  vacuolar H[+] ATPase 16kD subunit 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724476.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ55, P23380, Q0E9N6, Q53XD4, Q9V9D2
      Related
      FBpp0085486
      Conserved Domains (2) summary
      TIGR01100
      Location:15 → 122
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:90 → 157
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

    4. NM_165475.3 → NP_724475.1  vacuolar H[+] ATPase 16kD subunit 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ55, P23380, Q0E9N6, Q53XD4, Q9V9D2
      Related
      FBpp0085485
      Conserved Domains (2) summary
      TIGR01100
      Location:15 → 122
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:90 → 157
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23380.1 P23380

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