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    nsr novel spermatogenesis regulator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nsrprovided by FlyBase
    Official Full Name
    novel spermatogenesis regulatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034740
    Locus tag
    Dmel_CG3875
    See related
    AllianceGenome:FB:FBgn0034740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg3875; CG3875; Dmel\CG3875
    Summary
    Predicted to enable mRNA binding activity. Involved in post-transcriptional regulation of gene expression; sperm axoneme assembly; and sperm individualization. Located in nuclear speck. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nsr in Genome Data Viewer
    Location:
    58F4-58F4; 2-100 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22650556..22653595)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18538061..18541100)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 6d2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45268 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes. Ding Y, et al. PLoS Genet, 2010 Dec 23. PMID 21203494, Free PMC Article
    2. Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila. Yang S, et al. PLoS Genet, 2008 Jan. PMID 18208328, Free PMC Article
    3. Asymmetric sequence divergence of duplicate genes. Conant GC, et al. Genome Res, 2003 Sep. PMID 12952876, Free PMC Article
    4. Quantitative evolutionary genomics: differential gene expression and male reproductive success in Drosophila melanogaster. Drnevich JM, et al. Proc Biol Sci, 2004 Nov 7. PMID 15539352, Free PMC Article
    5. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative spermatogenesis regulator
    Names
    CG3875-PA
    CG3875-PB
    nsr-PA
    nsr-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22650556..22653595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299807.1 → NP_001286736.1  putative spermatogenesis regulator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286736.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E737, Q9W224
      Conserved Domains (1) summary
      cd02395
      Location:87 → 206
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

    2. NM_137838.3 → NP_611682.1  putative spermatogenesis regulator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E737, Q9W224
      Related
      FBpp0071772
      Conserved Domains (1) summary
      cd02395
      Location:87 → 206
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W224 Q9W224

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