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    Galphao G protein alpha subunit o [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galphaoprovided by FlyBase
    Official Full Name
    G protein alpha subunit oprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001122
    Locus tag
    Dmel_CG2204
    See related
    AllianceGenome:FB:FBgn0001122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha(o); bkh; Bkh; CG2204; DGalpha0; dGalphao; DGalpha[[o]]; dgo; dgoalpha; DG[[o]]; Dmel\CG2204; drogpad; DROGPAD; G(o)alpha47A; G-alpha-47A; G-oalpha; G-oalpha47a; G-oalpha47A; Galpha47A; Galphai/o; Galphao47A; Galpha[[047A]]; Galpha[[0]]; Galpha[[o]]; Galpha[[o]]47A; Go; Go-alpha; Goa; goalpha; Goalpha; Goalpha-47A; Goalpha47a; G[[oalpha]]; G[[o]]; G[[o]]alpha; like GNAO
    Summary
    Enables GTP binding activity. Involved in several processes, including behavioral response to starvation; negative regulation of synaptic assembly at neuromuscular junction; and nervous system development. Located in plasma membrane. Part of heterotrimeric G-protein complex. Is expressed in several structures, including female germline cell; ganglia; organism subdivision; somatic precursor cell; and visceral mesoderm derivative. Used to study developmental and epileptic encephalopathy 17. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Galphao in Genome Data Viewer
    Location:
    47A7-47A9; 2-62 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10437985..10465701)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6325490..6353206)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ran-binding protein M Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 49a1 Neighboring gene Chromatin assembly factor 1, p105 subunit Neighboring gene uncharacterized protein Neighboring gene withered

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Go contributes to olfactory reception in Drosophila melanogaster. Chatterjee A, et al. BMC Physiol, 2009 Nov 28. PMID 19943954, Free PMC Article
    2. Intrinsic Disorder-Based Design of Stabilizing Disulphide Bridge in Gαo Protein. Nagibina GS, et al. Protein Pept Lett, 2016. PMID 26786871
    3. Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system. Thambi NC, et al. J Biol Chem, 1989 Nov 5. PMID 2509464
    4. The Drosophila Go alpha-like G protein gene produces multiple transcripts and is expressed in the nervous system and in ovaries. de Sousa SM, et al. J Biol Chem, 1989 Nov 5. PMID 2509463
    5. Molecular characterization of Drosophila gene encoding G0 alpha subunit homolog. Yoon J, et al. J Biol Chem, 1989 Nov 5. PMID 2509462

    See all (176) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neomorphic Galphao mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies.
      Title: Neomorphic Gαo mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies.
    2. We have taken advantage of this approach to stabilize protein G alpha-go from Drosophila melanogaster. The designed SS-bridge increased by 4 degrees the melting temperature of one domain of protein G alpha-go .
      Title: Intrinsic Disorder-Based Design of Stabilizing Disulphide Bridge in Gαo Protein.
    3. The heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse and Ankyrin 2 as a target of Go signaling required for neuromuscular junction formation.
      Title: Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton.
    4. Data indicate that Kermit interacts with Go and another PCP component Vang during planar cell polarity (PCP).
      Title: Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity.
    5. Galphao47A is required in bitter-sensitive taste neurons for L-canavanine sensitivity.
      Title: Gαo is required for L-canavanine detection in Drosophila.
    6. Go is required for maximal physiological responses to multiple odorants in Drosophila, and olfactory receptor channel function and G-protein signaling are required for odor responsiveness.
      Title: Go contributes to olfactory reception in Drosophila melanogaster.
    7. Study shows that G-oalpha47A and Gbeta13F cooperate with Ggamma1 to maintain cardiac integrity in Drosophila.
      Title: Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila.
    8. The roles for Galpha(o) subunit (Go) in mediating the two distinct pathways transduced by Fz receptors in Drosophila.
      Title: Trimeric G protein-dependent frizzled signaling in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon ensheathment in central nervous system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sweet taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    G protein alpha subunit o
    Names
    CG2204-PA
    CG2204-PB
    CG2204-PC
    CG2204-PD
    CG2204-PE
    CG2204-PF
    CG2204-PG
    CG2204-PH
    CG2204-PI
    CG2204-PJ
    G protein alpha o subunit
    G protein o alpha 47A
    G protein oalpha 47A
    Galphao-PA
    Galphao-PB
    Galphao-PC
    Galphao-PD
    Galphao-PE
    Galphao-PF
    Galphao-PG
    Galphao-PH
    Galphao-PI
    Galphao-PJ
    brokenheart
    brokenhearted
    drogpad

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10437985..10465701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165772.4 → NP_724934.1  G protein alpha subunit o, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087359
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    2. NM_165773.3 → NP_724935.1  G protein alpha subunit o, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724935.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZB6, A4UZC1, B7FF70, P16377, P16378, P16707, Q540V8, Q8IGI5, Q9V5L5, Q9V5L6
      Related
      FBpp0087360
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    3. NM_176125.3 → NP_788305.1  G protein alpha subunit o, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788305.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087363
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    4. NM_176124.3 → NP_788304.1  G protein alpha subunit o, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788304.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087362
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    5. NM_176126.3 → NP_788306.1  G protein alpha subunit o, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788306.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087364
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    6. NM_176127.3 → NP_788307.1  G protein alpha subunit o, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788307.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Related
      FBpp0087365
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    7. NM_206080.2 → NP_995802.1  G protein alpha subunit o, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995802.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16378
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    8. NM_078960.5 → NP_523684.2  G protein alpha subunit o, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523684.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZB6, A4UZC1, B7FF70, P16377, P16378, P16707, Q540V8, Q8IGI5, Q9V5L5, Q9V5L6
      Related
      FBpp0087361
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    9. NM_206079.2 → NP_995801.1  G protein alpha subunit o, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995801.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZB6, A4UZC1, B7FF70, P16377, P16378, P16707, Q540V8, Q8IGI5, Q9V5L5, Q9V5L6
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    10. NM_001273940.1 → NP_001260869.1  G protein alpha subunit o, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEN0
      Conserved Domains (1) summary
      cd00066
      Location:1 → 121
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5AEN0 D5AEN0
    P16378.1 P16378

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