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    seq sequoia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    seqprovided by FlyBase
    Official Full Name
    sequoiaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028991
    Locus tag
    Dmel_CG32904
    See related
    AllianceGenome:FB:FBgn0028991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2R5; 49Fc; CG17724b; CG32904; CG4037; CG4055; Dmel\CG32904; l(2)49Fc; l(2)vr5; Seq; vr5
    Summary
    Involved in negative regulation of transcription by RNA polymerase II; neuron development; and open tracheal system development. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; head epidermis primordium; inner photoreceptor cell; nervous system; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See seq in Genome Data Viewer
    Location:
    49F4-49F7; 2-68 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13176553..13190086, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9064058..9077591, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene 1,4-Alpha-Glucan Branching Enzyme Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lysine demethylase 4B Neighboring gene Valyl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene Origin recognition complex subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tiling of the Drosophila epidermis by multidendritic sensory neurons. Grueber WB, et al. Development, 2002 Jun. PMID 12050135
    2. The function of Drosophila larval class IV dendritic arborization sensory neurons in the larval-pupal transition is separable from their function in mechanical nociception responses. Brown HE, et al. PLoS One, 2017. PMID 28910410, Free PMC Article
    3. An allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior. Dean KE, et al. PLoS One, 2013. PMID 24376789, Free PMC Article
    4. Dendrites. Jan YN, et al. Genes Dev, 2001 Oct 15. PMID 11641269
    5. The millennium of the dendrite? Matus A, et al. Neuron, 2000 Sep. PMID 11055426

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reported heterozygous mutations in sequoia (seq) dominantly exacerbated the trio mutant phenotype, and this seq-enhanced trio mutant genotype blocked the transition of third instar larvae from foragers to wanderers, a requisite behavioral transition prior to pupation.
      Title: The function of Drosophila larval class IV dendritic arborization sensory neurons in the larval-pupal transition is separable from their function in mechanical nociception responses.
    2. The findings suggest that seq may act as a context-dependent regulator of Notch signaling, and underscore the growing connection between Seq, Ttk, the PRDM family and Notch signaling.
      Title: sequoia controls the type I>0 daughter proliferation switch in the developing Drosophila nervous system.
    3. allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior
      Title: An allele of sequoia dominantly enhances a trio mutant phenotype to influence Drosophila larval behavior.
    4. The seq mutant phenotype arises, in part, owing to the loss of several crucial transcription factors known to be important in peripheral nervous system development such as D-Pax2, Prospero and Hamlet.
      Title: Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in R7 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R8 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in branching involved in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal cell fate specification, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sequoia
    Names
    CG32904-PA
    CG32904-PB
    lethal(2)49Fc
    seq-PA
    seq-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13176553..13190086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299450.1 → NP_001286379.1  sequoia, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286379.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFA2, Q7YU02
      Conserved Domains (1) summary
      sd00019
      Location:404 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001032244.2 → NP_001027415.1  sequoia, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z995, Q7YU02
      Conserved Domains (1) summary
      sd00019
      Location:404 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFA2 A0A0B4LFA2
    A1Z995 A1Z995
    Q95V81 Q95V81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
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