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    Wee1 Wee1 kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wee1provided by FlyBase
    Official Full Name
    Wee1 kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011737
    Locus tag
    Dmel_CG4488
    See related
    AllianceGenome:FB:FBgn0011737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4488; Dmel\CG4488; Dwee; dwee1; dWee1; Dwee1; wee; Wee; Wee 1; wee1; WEE1
    Summary
    Enables cyclin-dependent protein serine/threonine kinase inhibitor activity and protein tyrosine kinase activity. Involved in centrosome localization; microtubule cytoskeleton organization; and negative regulation of G2/M transition of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including gut section; larval brain; mesoderm anlage; pole plasm; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including WEE1 (WEE1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wee1 in Genome Data Viewer
    Location:
    27C4-27C4; 2-23 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6911090..6914138, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6911090..6914138, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Neuroligin 2 Neighboring gene mir-932 stem loop Neighboring gene RNA polymerase I subunit F Neighboring gene Rat1 5'-3' exoribonuclease Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene x16 splicing factor Neighboring gene nop5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry. Fasulo B, et al. Mol Biol Cell, 2012 Mar. PMID 22262459, Free PMC Article
    2. Measuring time during early embryonic development. Ferree PL, et al. Semin Cell Dev Biol, 2016 Jul. PMID 26994526, Free PMC Article
    3. The matrix protein Tiggrin regulates plasmatocyte maturation in Drosophila larva. Zhang CU, et al. Development, 2017 Jul 1. PMID 28526755, Free PMC Article
    4. Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development. Jin Z, et al. Genetics, 2008 Dec. PMID 18940789, Free PMC Article
    5. Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. Campbell SD, et al. Mol Biol Cell, 1995 Oct. PMID 8573790, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Relationships between DNA replication, chromosome condensation, and anaphase entry are mediated by the cell cycle kinases Grp (Chk1) and dWee1 (Wee1).
      Title: Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
    2. Phosphorylation of the KLP61F catalytic domain by dWee1 is important for the motor's function.
      Title: Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity.
    3. Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning.
      Title: Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning.
    4. Wee1 kinases can regulate mitotic entry in vivo during metazoan development even in cycles that lack a G2 phase.
      Title: Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Wee1 kinase
    Names
    CG4488-PA
    CG4488-PB
    Wee1 ortholog
    Wee1-PA
    Wee1-PB
    wee
    NP_001260167.1
    NP_477035.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6911090..6914138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273238.1 → NP_001260167.1  Wee1 kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260167.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54350, Q9VM70
      UniProtKB/TrEMBL
      M9PB57
      Conserved Domains (2) summary
      cd14051
      Location:238 → 516
      PTKc_Wee1; Catalytic domain of the Protein Tyrosine Kinase, Wee1
      pfam00069
      Location:239 → 515
      Pkinase; Protein kinase domain

    2. NM_057687.4 → NP_477035.1  Wee1 kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477035.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54350, Q9VM70
      UniProtKB/TrEMBL
      M9PB57
      Related
      FBpp0078999
      Conserved Domains (2) summary
      cd14051
      Location:238 → 516
      PTKc_Wee1; Catalytic domain of the Protein Tyrosine Kinase, Wee1
      pfam00069
      Location:239 → 515
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB57 M9PB57
    P54350.2 P54350

    Gene LinkOut

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