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    btd buttonhead [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    btdprovided by FlyBase
    Official Full Name
    buttonheadprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000233
    Locus tag
    Dmel_CG12653
    See related
    AllianceGenome:FB:FBgn0000233
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Btd; BTD; CG12653; Dmel\CG12653
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; TBP-class protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cephalic furrow formation; imaginal disc-derived leg morphogenesis; and regulation of transcription by RNA polymerase II. Is expressed in several structures, including anlage in statu nascendi; ganglia; head epidermis primordium; organism subdivision; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See btd in Genome Data Viewer
    Location:
    8F10-8F10; 1-29 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9694186..9697558)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9588219..9591591)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42657 Neighboring gene long non-coding RNA:CR44016 Neighboring gene long non-coding RNA:CR43498 Neighboring gene Sp1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila homologue of human Sp1 is a head-specific segmentation gene. Wimmer EA, et al. Nature, 1993 Dec 16. PMID 8259212
    2. buttonhead and D-Sp1: a novel Drosophila gene pair. Wimmer EA, et al. Mech Dev, 1996 Sep. PMID 8892232
    3. The Sp-family of transcription factors. Suske G. Gene, 1999 Oct 1. PMID 10570957
    4. The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors. Xie Y, et al. Elife, 2014 Oct 6. PMID 25285448, Free PMC Article
    5. Integration of the head and trunk segmentation systems controls cephalic furrow formation in Drosophila. Vincent A, et al. Development, 1997 Oct. PMID 9367430

    See all (182) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vivo analysis of the evolutionary conserved BTD-box domain of Sp1 and Btd during Drosophila development.
      Title: In vivo analysis of the evolutionary conserved BTD-box domain of Sp1 and Btd during Drosophila development.
    2. Btd prevents the premature differentiation by suppressing the expression of Prospero in immature intermediate neural progenitor cells. Btd functions cooperatively with Pointed P1 to promote the generation of the above cells.
      Title: The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors.
    3. Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor buttonhead.
      Title: Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor buttonhead.
    4. By simultaneously removing the function of two Sp8 orthologs, buttonhead (btd) and Sp1, during Drosophila embryogenesis, we find that adult leg development is completely abolished.
      Title: Non-redundant selector and growth-promoting functions of two sister genes, buttonhead and Sp1, in Drosophila leg development.
    5. Results show that buttonhead and Sp1 induce the formation and are required for the growth of the ventral imaginal discs.
      Title: The role of buttonhead and Sp1 in the development of the ventral imaginal discs of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior head segmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cephalic furrow formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in posterior head segmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    buttonhead
    Names
    CG12653-PA
    btd-PA
    button-head

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9694186..9697558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078545.3 → NP_511100.1  buttonhead [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511100.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24266, Q9W319
      Related
      FBpp0071314
      Conserved Domains (3) summary
      sd00017
      Location:338 → 357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:391 → 413
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:349 → 374
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24266.1 Q24266
    Q8SXR3 Q8SXR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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