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    Lcp2 Larval cuticle protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lcp2provided by FlyBase
    Official Full Name
    Larval cuticle protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0002533
    Locus tag
    Dmel_CG8697
    See related
    AllianceGenome:FB:FBgn0002533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2; CG8697; CP2; DmelLcp2; Dmel\CG8697; II; LCP-2; lcp2; LCP2; L[[3]]CP2
    Summary
    A structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in integumentary system and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lcp2 in Genome Data Viewer
    Location:
    44C6-44C6; 2-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8433797..8434785, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4321302..4322290, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Larval cuticle protein 1 Neighboring gene Larval cuticle protein 1 pseudogene Neighboring gene Larval cuticle protein 3 Neighboring gene Larval cuticle protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A duplication including the Y allele of Lcp2 and the TRIM retrotransposon at the Lcp locus on the degenerating neo-Y chromosome of Drosophila miranda: molecular structure and mechanisms by which it may have arisen. Steinemann M, et al. Genetics, 1993 Jun. PMID 8392013, Free PMC Article
    2. Synthetic pheromone biosynthesis activating neuropeptide gene expressed in a baculovirus expression system. Vakharia VN, et al. Insect Biochem Mol Biol, 1995 May. PMID 7787841
    3. Evolution of sex chromosomes: dosage compensation of the Lcp1-4 gene cluster on the evolving neo-X chromosome in Drosophila miranda. Steinemann S, et al. Insect Mol Biol, 2007 Apr. PMID 17352708
    4. Chromatin structure at the 44D larval cuticle gene locus in Drosophila: the effect of a transposable element insertion. Eissenberg JC, et al. Nucleic Acids Res, 1984 Dec 11. PMID 6096816, Free PMC Article
    5. The cuticle genes of drosophila: a developmentally regulated gene cluster. Snyder M, et al. Cell, 1981 Jul. PMID 6168386

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in larval chitin-based cuticle development IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    larval cuticle protein 2
    Names
    CG8697-PA
    CG8697-PB
    Lcp2-PA
    Lcp2-PB
    cuticle p. II
    gene II

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8433797..8434785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273873.2 → NP_001260802.1  larval cuticle protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260802.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0HBT8, P07187, Q9V4T0
      UniProtKB/TrEMBL
      A0A0B4KEG7
      Conserved Domains (1) summary
      pfam00379
      Location:42 → 89
      Chitin_bind_4; Insect cuticle protein

    2. NM_057272.4 → NP_476620.1  larval cuticle protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0HBT8, P07187, Q9V4T0
      UniProtKB/TrEMBL
      A0A0B4KEG7
      Related
      FBpp0087840
      Conserved Domains (1) summary
      pfam00379
      Location:42 → 89
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEG7 A0A0B4KEG7
    P07187.1 P07187

    Gene LinkOut

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