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    E(spl)mdelta-HLH Enhancer of split mdelta, helix-loop-helix [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E(spl)mdelta-HLHprovided by FlyBase
    Official Full Name
    Enhancer of split mdelta, helix-loop-helixprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002734
    Locus tag
    Dmel_CG8328
    See related
    AllianceGenome:FB:FBgn0002734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHc14; CG8328; Dmel\CG8328; E(Spl) HLH-m delta; E(spl) mdelta; E(Spl)-HLH-mdelta; E(spl)-mdelta; E(spl)delta; E(spl)mC; E(spl)mdelta; E(spl)Mdelta; HLH-mdelta; HLHmC; HLHMD; HLHmdelta; HLHMdelta; mC; md; mdelta; Mdelta; mdelta0.5
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Involved in several processes, including compound eye photoreceptor cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of neuroblast proliferation. Predicted to be active in nucleus. Is expressed in several structures, including embryonic segment; epithelium; eye photoreceptor cell; germ layer; and head epidermis primordium. Orthologous to human HES2 (hes family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E(spl)mdelta-HLH in Genome Data Viewer
    Location:
    96F9-96F9; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25997621..25998633)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21823343..21824355)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Neurofibromin 1 Neighboring gene uncharacterized protein Neighboring gene Enhancer of split mgamma, helix-loop-helix Neighboring gene long non-coding RNA:CR45037

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cadherin Flamingo mediates level-dependent interactions that guide photoreceptor target choice in Drosophila. Chen PL, et al. Neuron, 2008 Apr 10. PMID 18400160, Free PMC Article
    2. The Notch target E(spl)mδ is a muscle-specific gene involved in methylmercury toxicity in motor neuron development. Engel GL, et al. Neurotoxicol Teratol, 2014 May-Jun. PMID 24632433, Free PMC Article
    3. A network of cadherin-mediated interactions polarizes growth cones to determine targeting specificity. Schwabe T, et al. Cell, 2013 Jul 18. PMID 23870124, Free PMC Article
    4. Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting. Prakash S, et al. Dev Biol, 2009 Dec 1. PMID 19766621, Free PMC Article
    5. Review: myogenic and muscle toxicity targets of environmental methylmercury exposure. Tam LM, et al. Arch Toxicol, 2024 Jun. PMID 38546836,

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R1/R6 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of split mdelta, helix-loop-helix
    Names
    CG8328-PA
    E(spl) region
    E(spl) region transcript mdelta
    E(spl)mdelta-HLH-PA
    enhancer of split region transcript HLHmC
    split locus enhancer protein mC
    transcript mdelta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25997621..25998633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079779.3 → NP_524503.2  enhancer of split mdelta, helix-loop-helix [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524503.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01071, Q01897, Q4V723, Q56MT6, Q56MU1, Q56MU3, Q56MU4, Q56MU6, Q56MU8, Q56MV0, Q56MV5, Q56MV6, Q56MW2, Q56MW7, Q56MW9, Q56MX9, Q56MY0, Q56MY1, Q56N19, Q56N23, Q5S485, Q5S4A9, Q5S4K5
      Related
      FBpp0084328
      Conserved Domains (2) summary
      smart00511
      Location:91 → 135
      ORANGE; Orange domain
      cd19741
      Location:9 → 77
      bHLH-O_ESMB_like; basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster enhancer of split mbeta protein (ESMB) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01071.1 Q01071

    Gene LinkOut

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