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    mnd minidiscs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mndprovided by FlyBase
    Official Full Name
    minidiscsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002778
    Locus tag
    Dmel_CG3297
    See related
    AllianceGenome:FB:FBgn0002778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3297; Dmel\CG3297; l(3)B5; l(3)ds-5; l(3)ds5; l(3)o52; l(3)SG29; md; Mnd; MND; SG29
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Involved in L-leucine import across plasma membrane. Predicted to be located in membrane. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; lung squamous cell carcinoma; and lysinuric protein intolerance. Orthologous to several human genes including SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mnd in Genome Data Viewer
    Location:
    71A4-71B1; 3-42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14985100..14991667)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14978200..14984767)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Zinc/iron regulated transporter-related protein 71B Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene Proteasome beta2 subunit Neighboring gene Reversion-inducing-cysteine-rich protein with kazal motifs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A LAT1-Like Amino Acid Transporter Regulates Neuronal Activity in the Drosophila Mushroom Bodies.
      Title: A LAT1-Like Amino Acid Transporter Regulates Neuronal Activity in the Drosophila Mushroom Bodies.
    2. Direct sensing of nutrients via a LAT1-like transporter Mnd in Drosophila insulin-producing cells has been demonstrated.
      Title: Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells.
    3. Data show that CG2791 and two Drosophila homologues of the mammalian CD98 light chains, Mnd (Minidiscs) and JhI-21, are required for normal levels of System L transport.
      Title: Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    minidiscs
    Names
    CG3297-PA
    CG3297-PC
    CG3297-PD
    minidisks
    mnd-PA
    mnd-PC
    mnd-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14985100..14991667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168601.3 → NP_730006.1  minidiscs, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMK0, Q7KUL6, Q9Y1A7
      Related
      FBpp0075379
      Conserved Domains (1) summary
      TIGR00911
      Location:22 → 496
      2A0308; L-type amino acid transporter

    2. NM_168600.3 → NP_730005.3  minidiscs, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730005.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMK0, Q7KUL6, Q9Y1A7
      Conserved Domains (1) summary
      TIGR00911
      Location:22 → 496
      2A0308; L-type amino acid transporter

    3. NM_079350.5 → NP_524074.1  minidiscs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMK0, Q7KUL6, Q9Y1A7
      Related
      FBpp0075380
      Conserved Domains (1) summary
      TIGR00911
      Location:22 → 496
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y1A7 Q9Y1A7

    Gene LinkOut

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