tud tudor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tudprovided by FlyBase
Official Full Name: tudorprovided by FlyBase
Primary source: FLYBASE:FBgn0003891
Locus tag: Dmel_CG9450
See related: AllianceGenome:FB:FBgn0003891
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9450; Dmel\CG9450; R5_2R:17070527..17070890; tu; Tud; TUD; Tudor
Summary: Enables methylation-dependent protein binding activity. Involved in P granule organization; pole cell development; and secondary piRNA processing. Located in several cellular components, including P granule; cytosol; and mitochondrion. Is expressed in several structures, including adult head; germarium; germline cell; ovariole; and vitelline membrane. Orthologous to human TDRD15 (tudor domain containing 15) and TDRD6 (tudor domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 57C8-57C9; 2-93 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21183322..21192913)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17070827..17080418)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila germ granules are assembled from protein components through different modes of competing interactions with the multi-domain Tudor protein.
Title: Drosophila germ granules are assembled from protein components through different modes of competing interactions with the multi-domain Tudor protein.
Tudor protein's structural flexibility suggests a mechanism for the recruitment of glycolytic enzymes to the granules.
Title: Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements.
The overall spatial organization of the tandem domains of Tudor protein, is reported.
Title: Structure and domain organization of Drosophila Tudor.
Drosophila TUDOR domain-containing proteins interact with Vreteno and the Tdrd12 family, essential primary piRNA pathway factors
Title: A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.
Oskar recruits two downstream components of the polar granules, Vasa and Tudor, independently from each other: Vasa directly interacts with Oskar while Valois mediates the recruitment of Tudor by interacting with Oskar and Tudor
Title: Targeting and anchoring Tudor in the pole plasm of the Drosophila oocyte.
the C-terminal moiety of Tud contains all the information necessary for its localization in the nuage and pole plasm and its pole cell-forming activity
Title: C-terminal moiety of Tudor contains its in vivo activity in Drosophila.
Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage
Title: Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.
maternal tudor mutation was found to increase life span in males but not in females
Title: Identifying sexual differentiation genes that affect Drosophila life span.
Germ plasm assembly requires symmetrically dimethylated modification of Aub by dPRMT5, which, in turn, is required for binding to Tudor.
Title: Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization.
in germline cells, piRNAs are quality-controlled by dPRMT5 that modifies PIWI proteins, in tight association with Tud
Title: Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables methylation-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in P granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in mitochondrial RNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm assembly	TAS Traceable Author Statement more info	PubMed
involved_in secondary piRNA processing	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in P granule	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pole plasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tudor

Names: CG9450-PA; CG9450-PB; TUDOR; tud-PA; tud-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

21183322..21192913

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057425.3 → NP_476773.1 tudor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476773.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25823, Q9W2J8

Related

FBpp0071508

Conserved Domains (4) summary

cd04508
Location:2396 → 2437

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

smart00333
Location:1354 → 1411

TUDOR; Tudor domain

pfam00567
Location:406 → 524

TUDOR; Tudor domain

pfam07223
Location:198 → 397

DUF1421; Protein of unknown function (DUF1421)
NM_001299736.1 → NP_001286665.1 tudor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286665.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LG05

Conserved Domains (4) summary

cd04508
Location:2393 → 2434

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

smart00333
Location:1351 → 1408

TUDOR; Tudor domain

pfam00567
Location:406 → 524

TUDOR; Tudor domain

pfam07223
Location:198 → 397

DUF1421; Protein of unknown function (DUF1421)