wbl windbeutel [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wblprovided by FlyBase
Official Full Name: windbeutelprovided by FlyBase
Primary source: FLYBASE:FBgn0004003
Locus tag: Dmel_CG7225
See related: AllianceGenome:FB:FBgn0004003
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7225; Dmel\CG7225; Wbl; wbt; wind; Wind; Windb
Summary: Enables protein homodimerization activity. Involved in dorsal/ventral axis specification; protein folding in endoplasmic reticulum; and regulation of growth. Located in endoplasmic reticulum. Is expressed in several structures, including anterior-posterior subdivision of organism; dorsal epidermis primordium; embryonic dorsal epidermis; gland; and head epidermis primordium. Orthologous to human ERP29 (endoplasmic reticulum protein 29). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19249395..19250917)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15136900..15138422)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

description of the three-dimensional structure of Wind at 1.9-A resolution and identify a candidate surface for interaction with Pipe
Title: Crystal structure and functional analysis of Drosophila Wind, a protein-disulfide isomerase-related protein.
we map an essential substrate binding site in Wind to the vicinity of an exposed cluster of tyrosines within the thioredoxin fold domain.
Title: Mapping of a substrate binding site in the protein disulfide isomerase-related chaperone wind based on protein function and crystal structure.
Molecular model of Wind.
Title: Structural elucidation of the PDI-related chaperone Wind with the help of mutants.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	NAS Non-traceable Author Statement more info	PubMed
involved_in embryo development ending in birth or egg hatching	TAS Traceable Author Statement more info	PubMed
involved_in maternal specification of dorsal/ventral axis, oocyte, soma encoded	TAS Traceable Author Statement more info	PubMed
involved_in protein folding in endoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

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