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    TkR99D Tachykinin-like receptor at 99D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TkR99Dprovided by FlyBase
    Official Full Name
    Tachykinin-like receptor at 99Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004622
    Locus tag
    Dmel_CG7887
    See related
    AllianceGenome:FB:FBgn0004622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0131005.11; anon-WO0131005.9; CG7887; Dmel\CG7887; DmTRPR; dtkr; Dtkr; DTKR; l(3)s2222; Tak-r; TAKR; Takr99D; TakR99D; TAKR99D; Tk-R 99D; Tkr99D; TKR99D; TLR2_DROME
    Summary
    Enables tachykinin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; detection of chemical stimulus involved in sensory perception of smell; and positive regulation of sensory perception of pain. Located in plasma membrane. Is expressed in several structures, including ganglia; gut section; protocerebrum; specialized Malpighian tubule cell; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in asthma; developmental disorder of mental health; exercise-induced bronchoconstriction; and hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to several human genes including TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TkR99D in Genome Data Viewer
    Location:
    99C8-99D1; 3-100 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29950796..29969447, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25776518..25795169, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit alpha Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 13B Neighboring gene uncharacterized protein Neighboring gene Acid phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides. Li XJ, et al. EMBO J, 1991 Nov. PMID 1717263, Free PMC Article
    2. Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster. Li XJ, et al. J Biol Chem, 1992 Jan 5. PMID 1370455
    3. Local peptidergic signaling in the antennal lobe shapes olfactory behavior. Winther AM, et al. Fly (Austin), 2010 Apr-Jun. PMID 20224300
    4. Tachykinin-related peptides and their receptors in invertebrates: a current view. Van Loy T, et al. Peptides, 2010 Mar. PMID 19781585
    5. Functional comparison of two evolutionary conserved insect neurokinin-like receptors. Poels J, et al. Peptides, 2007 Jan. PMID 17141920

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables tachykinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tachykinin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tachykinin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tachykinin receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tachykinin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tachykinin-like receptor at 99D
    Names
    CG7887-PA
    CG7887-PB
    CG7887-PC
    DTK receptor
    TkR99D-PA
    TkR99D-PB
    TkR99D-PC
    drosophila tachykinin receptor
    tachykinin receptor
    tachykinin-like receptor at 99D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29950796..29969447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170301.1 → NP_001163772.1  Tachykinin-like receptor at 99D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ17
      Conserved Domains (2) summary
      pfam00001
      Location:118 → 381
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:113 → 396
      7tm_4; Olfactory receptor

    2. NM_079832.3 → NP_524556.2  Tachykinin-like receptor at 99D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524556.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30975, Q8T0S8, Q9VAD2
      Related
      FBpp0084873
      Conserved Domains (2) summary
      pfam00001
      Location:118 → 381
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:113 → 396
      7tm_4; Olfactory receptor

    3. NM_001276163.1 → NP_001263092.1  Tachykinin-like receptor at 99D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263092.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHV8
      Conserved Domains (2) summary
      pfam00001
      Location:118 → 381
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:113 → 396
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHV8 A0A0B4KHV8
    E1JJ17 E1JJ17
    P30975.2 P30975

    Gene LinkOut

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