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    elB elbow B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34844, updated on 17-Dec-2024

    Summary

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    Official Symbol
    elBprovided by FlyBase
    Official Full Name
    elbow Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004858
    Locus tag
    Dmel_CG4220
    See related
    AllianceGenome:FB:FBgn0004858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS06238.3; CG4220; Dmel\CG4220; el; elb; Elb; ElB; elbow; Elbow; el[B]; P10
    Summary
    Involved in several processes, including compound eye photoreceptor fate commitment; eye-antennal disc development; and open tracheal system development. Located in nuclear chromosome. Is expressed in several structures, including epithelium; gut section; imaginal disc; larval muscle cell; and tracheal primordium. Orthologous to human ZNF703 (zinc finger protein 703). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See elB in Genome Data Viewer
    Location:
    35B1-35B1; 2-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14390628..14409549, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14390628..14409549, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene spellchecker1 Neighboring gene pickpocket Neighboring gene long non-coding RNA:CR44733 Neighboring gene Partner of Bursicon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pickpocket1 is an ionotropic molecular sensory transducer. Boiko N, et al. J Biol Chem, 2012 Nov 16. PMID 23033486, Free PMC Article
    2. Evolution of the NET (NocA, Nlz, Elbow, TLP-1) protein family in metazoans: insights from expression data and phylogenetic analysis. Pereira F, et al. Sci Rep, 2016 Dec 8. PMID 27929068, Free PMC Article
    3. Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae. Zhong L, et al. Curr Biol, 2010 Mar 9. PMID 20171104, Free PMC Article
    4. A stage-specific factor confers Fab-7 boundary activity during early embryogenesis in Drosophila. Aoki T, et al. Mol Cell Biol, 2008 Feb. PMID 18039839, Free PMC Article
    5. Notch signaling links interactions between the C/EBP homolog slow border cells and the GILZ homolog bunched during cell migration. Levine B, et al. Dev Biol, 2007 May 1. PMID 17383627

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we show that Elb/Noc specifically interact with the transcription factor Orthodenticle (Otd)/Otx, a crucial regulator of rhodopsin gene transcription.
      Title: Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins elbow and no ocelli.
    2. identified a factor, called early boundary activity (Elba), that confers Fab-7 boundary activity during early embryogenesis
      Title: A stage-specific factor confers Fab-7 boundary activity during early embryogenesis in Drosophila.
    3. regulation of the size of the eye-head primordium by elbow and no ocelli is crucial for proper fate specification and generation of the adult structures
      Title: Growth control in the proliferative region of the Drosophila eye-head primordium: the elbow-noc gene complex.
    4. Results identify two proteins, elbow and noc, which form a complex and participate in the determination of specific tracheal branch fates.
      Title: Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eye-antennal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived appendage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in leg disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    elbow B
    Names
    CG4220-PC
    CG4220-PD
    ElbowB
    elB-PC
    elB-PD
    elbow

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14390628..14409549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205990.2 → NP_995712.1  elbow B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995712.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJS8
      Conserved Domains (2) summary
      PRK13914
      Location:110 → 187
      PRK13914; invasion associated secreted endopeptidase; Provisional
      sd00017
      Location:438 → 465
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_078842.5 → NP_523566.4  elbow B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523566.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KT93, Q8IGL9, Q8MTC6, Q9NKC3, Q9VJS8
      Conserved Domains (3) summary
      PRK13914
      Location:111 → 188
      PRK13914; invasion associated endopeptidase
      sd00017
      Location:439 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437 → 466
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJS8.4 Q9VJS8

    Gene LinkOut

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    Other Literature Sources
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