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    Cyp4d1 Cytochrome P450 4d1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31188, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4d1provided by FlyBase
    Official Full Name
    Cytochrome P450 4d1provided by FlyBase
    Primary source
    FLYBASE:FBgn0005670
    Locus tag
    Dmel_CG3656
    See related
    AllianceGenome:FB:FBgn0005670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4d1; CG3656; cyp4d1; Cyp4D1; CYP4D1; CYP6D1; Cyt-P450-4D1; Dmel\CG3656; EG:87B1.1; P-450; P450
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic/larval fat body; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4d1 in Genome Data Viewer
    Location:
    2D5-2D6; 1-0.6 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2159145..2162180, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2053178..2056213, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Phosphogluconate dehydrogenase Neighboring gene bcn92 Neighboring gene wings apart-like Neighboring gene uncharacterized protein Neighboring gene mir-3641 stem loop Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 A subunit Neighboring gene Cytochrome P450 4d14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction by alkaloids and phenobarbital of Family 4 Cytochrome P450s in Drosophila: evidence for involvement in host plant utilization. Danielson PB, et al. Mol Gen Genet, 1998 Jul. PMID 9738880
    2. Hormone receptor-like in 96 and Broad-Complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cells. Lin GG, et al. Insect Mol Biol, 2011 Feb. PMID 21029232, Free PMC Article
    3. Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster. Davies L, et al. Insect Biochem Mol Biol, 2006 Oct. PMID 17027846
    4. Insect cytochromes P450: diversity, insecticide resistance and tolerance to plant toxins. Scott JG, et al. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 1998 Nov. PMID 9972456
    5. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Maïbèche-Coisne M, et al. Biochem Biophys Res Commun, 2000 Jul 14. PMID 10891384

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4d1
    Names
    CG3656-PA
    CG3656-PB
    Cyp4d1-PA
    Cyp4d1-PB
    P450 CYPD1
    cytochrome P450
    cytochrome P450 4D1
    cytochrome P450-4d1
    NP_476907.2
    NP_726797.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2159145..2162180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166932.2 → NP_726797.1  cytochrome P450 4d1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0F6QEL7, Q8MS75
      Related
      FBpp0070411
      Conserved Domains (1) summary
      pfam00067
      Location:57 → 498
      p450; Cytochrome P450

    2. NM_057559.4 → NP_476907.2  cytochrome P450 4d1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476907.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0F6T2F1, A0A0F6T2F9
      Related
      FBpp0070412
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 507
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33269.2 P33269
    Q8MS75 Q8MS75

    Gene LinkOut

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