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    Cyp4e3 Cytochrome P450 4e3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4e3provided by FlyBase
    Official Full Name
    Cytochrome P450 4e3provided by FlyBase
    Primary source
    FLYBASE:FBgn0015035
    Locus tag
    Dmel_CG4105
    See related
    AllianceGenome:FB:FBgn0015035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4e3; CG4105; cyp4e3; Cyp4E3; CYP4E3; Dmel\CG4105; P-450; P450
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Located in endoplasmic reticulum. Is expressed in adult head; embryonic/larval fat body; embryonic/larval midgut; and epithelium. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4e3 in Genome Data Viewer
    Location:
    30C7-30C7; 2-36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9747839..9750071, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9747839..9750071, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Nckx30C Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46529 Neighboring gene zinc finger protein 30C Neighboring gene TBP-associated factor 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Terhzaz S, et al. Insect Biochem Mol Biol, 2015 Dec. PMID 26073628, Free PMC Article
    2. Cyclophosphamide in Drosophila promotes genes and transposable elements differential expression and mitochondrial dysfunction. Stoffel TJR, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2020 Apr. PMID 31982542
    3. Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs. Muraoka Y, et al. Exp Neurol, 2018 Dec. PMID 30165075
    4. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871
    5. A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Cruz C, et al. Genetics, 2009 Nov. PMID 19737745, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 4e3
    Names
    CG4105-PA
    Cyp4e3-PA
    cytochrome P450
    cytochrome P450-4e3
    NP_523527.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9747839..9750071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078803.2 → NP_523527.1  cytochrome P450 4e3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523527.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24128, Q9VL92
      UniProtKB/TrEMBL
      A8E6N0
      Related
      FBpp0079515
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 468
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL92.1 Q9VL92

    Gene LinkOut

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