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    Orc5 Origin recognition complex subunit 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orc5provided by FlyBase
    Official Full Name
    Origin recognition complex subunit 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0015271
    Locus tag
    Dmel_CG7833
    See related
    AllianceGenome:FB:FBgn0015271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00941.8; br39; CG7833; D-orc5; Dmel\CG7833; DmOrc5; DmORC5; dORC5; l(2)34Df; l(2)br39; ORC; orc5; ORC5
    Summary
    Enables ribonucleoprotein complex binding activity. Involved in DNA replication initiation; mitotic chromosome condensation; and mitotic spindle organization. Located in nucleus. Part of nuclear origin of replication recognition complex. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic/larval midgut primordium; ganglia; and head epidermis primordium. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Orc5 in Genome Data Viewer
    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13829837..13831576)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13829837..13831576)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene DNA polymerase gamma subunit 1 Neighboring gene Actin-related protein 2/3 complex, subunit 1 Neighboring gene DNA polymerase gamma subunit 2 Neighboring gene RNA polymerase II subunit C Neighboring gene Glutamyl-tRNA amidotransferase, subunit C Neighboring gene mitochondrial ribosomal protein S23 Neighboring gene Centaurin gamma 1A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila homolog of yeast ORC: correction. Gossen M, et al. Science, 1996 Mar 8. PMID 8596901
    2. A Drosophila homolog of the yeast origin recognition complex. Gossen M, et al. Science, 1995 Dec 8. PMID 7502079
    3. Drosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6. Balasov M, et al. Am J Med Genet A, 2015 Nov. PMID 26139588, Free PMC Article
    4. Forced binding of the origin of replication complex to chromosomal sites in Drosophila S2 cells creates an origin of replication. Crevel G, et al. J Cell Sci, 2012 Feb 15. PMID 22421364
    5. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Clarey MG, et al. Nat Struct Mol Biol, 2006 Aug. PMID 16829958

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear origin of replication recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of origin recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 5
    Names
    CG7833-PA
    Orc5-PA
    lethal(2)34Df

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13829837..13831576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057784.8 → NP_477132.1  origin recognition complex subunit 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477132.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24169, Q9V398
      Related
      FBpp0080120
      Conserved Domains (2) summary
      pfam13191
      Location:12 → 151
      AAA_16; AAA ATPase domain
      pfam14630
      Location:178 → 456
      ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24169.1 Q24169

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