vri vrille [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: vriprovided by FlyBase
Official Full Name: vrilleprovided by FlyBase
Primary source: FLYBASE:FBgn0016076
Locus tag: Dmel_CG14029
See related: AllianceGenome:FB:FBgn0016076
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: argo; CG14029; DM16; Dmel\CG14029; jf23; l(2)25Db; l(2)jf23; mat(2)ea-G; mat(2)earlyRS32; mel_vri; Vri; VRI; Vrille
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including chaeta morphogenesis; imaginal disc-derived wing hair organization; and open tracheal system development. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; epithelium; gut section; and pacemaker neurons. Orthologous to human NFILZ (NFIL3 like basic leucine zipper) and NFIL3 (nuclear factor, interleukin 3 regulated). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25D4-25D5; 2-16 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5288944..5311223)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5288944..5311223)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we demonstrate that Vri, the ortholog of the vertebrate NFIL3/E4B4 transcription factor, is a major genetic regulator of cardiac aging. Vri overexpression leads to major heart dysfunctions
Title: dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila.
E23 forms its own feedback loop in the ecdysone response to control circadian oscillation through ecdysone-mediated vrille expression.
Title: Membrane-bound transporter controls the circadian transcription of clock genes in Drosophila.
Vrille mutants interfered with tracheal development, but did not produce defects in gut morphology.
Title: vrille is required to ensure tracheal integrity in Drosophila embryo.
Results show that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular differentiation in response to the hormone.
Title: Genomic mapping of binding regions for the Ecdysone receptor protein complex.
Clk, vri, and Pdp-1 have roles in controlling Drosophila circadian oscillations, as shown in a simulation
Title: Simulation of Drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK.
role for VRI in the rhythmic repression of output genes that cycle in phase with Clk
Title: VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator.
Results suggest that vrille is required for normal cell growth and proliferation via the regulation of the actin cytoskeleton.
Title: The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived wing hair organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in rhythmic behavior	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vrille

Names: CG14029-PA; CG14029-PC; CG14029-PD; CG14029-PE; CG14029-PF; lethal(2)25Db; maternal effect early arrest G; vri-PA; vri-PC; vri-PD; vri-PE; vri-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5288944..5311223

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298694.1 → NP_001285623.1 vrille, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285623.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KTN9, Q8MZ04

Conserved Domains (1) summary

cd14694
Location:119 → 178

bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
NM_164639.2 → NP_723075.1 vrille, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723075.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KTN9, Q8MZ04

Related

FBpp0078705

Conserved Domains (1) summary

cd14694
Location:119 → 178

bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
NM_001298695.1 → NP_001285624.1 vrille, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285624.1

Status: REVIEWED

UniProtKB/TrEMBL

O18660, Q9VMS4

Conserved Domains (1) summary

cd14694
Location:238 → 297

bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
NM_057843.4 → NP_477191.1 vrille, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477191.1

Status: REVIEWED

UniProtKB/TrEMBL

O18660, Q9VMS4

Related

FBpp0078706

Conserved Domains (1) summary

cd14694
Location:238 → 297

bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
NM_001144320.2 → NP_001137792.1 vrille, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137792.1

Status: REVIEWED

UniProtKB/TrEMBL

O18660, Q9VMS4

Conserved Domains (1) summary

cd14694
Location:238 → 297

bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain