ari-1 ariadne 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ari-1provided by FlyBase
Official Full Name: ariadne 1provided by FlyBase
Primary source: FLYBASE:FBgn0017418
Locus tag: Dmel_CG5659
See related: AllianceGenome:FB:FBgn0017418
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAS65398.1; ari; Ari-1; ari-1a; ARI1_DROME; CG5659; Dmel\CG5659; HL-V; l(1)16Fj
Summary: Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of neurogenesis; positive regulation of proteasomal protein catabolic process; and protein monoubiquitination. Located in cytosol and nucleus. Is expressed in several structures, including adult central nervous system; follicle cell; germline cell; gonad; and larval muscle system. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 16F7-16F7; 1-59 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18130392..18137784, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18024425..18031817, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.
Title: The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.
Variants in ARI-1 are associated with nuclear clustering and morphology defects in larval muscles and thus developing aortic aneurysms.
Title: Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.
Ariadne-1a binds specifically the isoform A of EcR and ubiquitylates it
Title: Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c18132003-18131319 mobile_element_type = transposon:1360{}154

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ariadne 1

Names: Ariadne-1; CG5659-PA; CG5659-PB; CG5659-PC; CG5659-PD; CG5659-PE; CG5659-PF; ari-1-PA; ari-1-PB; ari-1-PC; ari-1-PD; ari-1-PE; ari-1-PF; ariadne

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

18130392..18137784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258807.3 → NP_001245736.1 ariadne 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245736.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ9, Q94981

UniProtKB/TrEMBL

A4V4Q7

Conserved Domains (2) summary

smart00647
Location:204 → 264

IBR; In Between Ring fingers

pfam01485
Location:286 → 326

IBR; IBR domain, a half RING-finger domain
NM_001272742.2 → NP_001259671.1 ariadne 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259671.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ9, Q94981

UniProtKB/TrEMBL

A4V4Q7

Conserved Domains (2) summary

smart00647
Location:204 → 264

IBR; In Between Ring fingers

pfam01485
Location:286 → 326

IBR; IBR domain, a half RING-finger domain
NM_001272743.1 → NP_001259672.1 ariadne 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259672.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ9, Q94981

UniProtKB/TrEMBL

A4V4Q7

Conserved Domains (2) summary

smart00647
Location:204 → 264

IBR; In Between Ring fingers

pfam01485
Location:286 → 326

IBR; IBR domain, a half RING-finger domain
NM_078675.4 → NP_523399.1 ariadne 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523399.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ9, Q94981

UniProtKB/TrEMBL

A4V4Q7

Related

FBpp0088499

Conserved Domains (2) summary

smart00647
Location:204 → 264

IBR; In Between Ring fingers

pfam01485
Location:286 → 326

IBR; IBR domain, a half RING-finger domain
NM_206777.2 → NP_996500.1 ariadne 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996500.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ9, Q94981

UniProtKB/TrEMBL

A4V4Q7

Conserved Domains (2) summary

smart00647
Location:204 → 264

IBR; In Between Ring fingers

pfam01485
Location:286 → 326

IBR; IBR domain, a half RING-finger domain
NM_167610.4 → NP_728145.1 ariadne 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728145.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ9, Q94981

UniProtKB/TrEMBL

A4V4Q7

Related

FBpp0088500

Conserved Domains (2) summary

smart00647
Location:204 → 264

IBR; In Between Ring fingers

pfam01485
Location:286 → 326

IBR; IBR domain, a half RING-finger domain