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    RpL14 Ribosomal protein L14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpL14provided by FlyBase
    Official Full Name
    Ribosomal protein L14provided by FlyBase
    Primary source
    FLYBASE:FBgn0017579
    Locus tag
    Dmel_CG6253
    See related
    AllianceGenome:FB:FBgn0017579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey193U; anon-EST:Posey6; CG6253; Dmel\CG6253; L14; L14e; M(3); M(3)66; M(3)66D; M66D; Rp L14; rpl14; RPL14
    Summary
    A structural constituent of ribosome. Involved in negative regulation of neuron apoptotic process. Located in cytosolic ribosome. Is expressed in adult head and adult heart. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human RPL14 (ribosomal protein L14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpL14 in Genome Data Viewer
    Location:
    66D8-66D8; 3-26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8601006..8602392)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8594106..8595492)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene rhea Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Negative elongation factor E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. First steps towards underdominant genetic transformation of insect populations. Reeves RG, et al. PLoS One, 2014. PMID 24844466, Free PMC Article
    2. Primary structure of Drosophila ribosomal protein L14 and identification of conserved protein motifs. Haynes SR. DNA Seq, 1997. PMID 9522130
    3. Silencing the Drosophila ribosomal protein L14 gene using targeted RNA interference causes distinct somatic anomalies. Enerly E, et al. Gene, 2003 Nov 27. PMID 14597387
    4. The Drosophila ribosomal protein L14-encoding gene, identified by a novel Minute mutation in a dense cluster of previously undescribed genes in cytogenetic region 66D. Saebøe-Larssen S, et al. Mol Gen Genet, 1997 Jun. PMID 9236770
    5. Drosophila S6 kinase: a regulator of cell size. Montagne J, et al. Science, 1999 Sep 24. PMID 10497130

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein L14
    Names
    60 S ribosomal protein L14
    CG6253-PA
    Minute(3)66D
    RpL14-PA
    minute (3)66D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8601006..8602392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079251.4 → NP_523975.1  ribosomal protein L14 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55841, Q9VSM3
      UniProtKB/TrEMBL
      A0A1B2AIV7, Q5U0W4
      Related
      FBpp0076359
      Conserved Domains (2) summary
      cd06088
      Location:7 → 81
      KOW_RPL14; KOW motif of Ribosomal Protein L14
      pfam01929
      Location:46 → 120
      Ribosomal_L14e; Ribosomal protein L14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55841.1 P55841
    Q5BIL1 Q5BIL1

    Gene LinkOut

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