U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ilp7 Insulin-like peptide 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31328, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ilp7provided by FlyBase
    Official Full Name
    Insulin-like peptide 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0044046
    Locus tag
    Dmel_CG13317
    See related
    AllianceGenome:FB:FBgn0044046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13317; dilp; Dilp; DILP; Dilp 7; DILP 7; dilp-7; dILP-7; DILP-7; dilp7; dIlp7; dILP7; Dilp7; DILP7; DILPs; dlp; Dmel\CG13317; Ilp; Ilp-7; ilp7; ILP7; ILPs
    Summary
    Predicted to enable insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including Ilp7 neuron; female reproductive system; fruitless expressing neurons; ganglia; and hindgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ilp7 in Genome Data Viewer
    Location:
    3E2-3E2; 1-4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3667621..3668845)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3561654..3562878)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Dpr-interacting protein alpha Neighboring gene pickpocket 8 Neighboring gene uncharacterized protein Neighboring gene Allatostatin A receptor 1 Neighboring gene Poly(ADP-ribose) glycohydrolase Neighboring gene long non-coding RNA:CR45102 Neighboring gene Mnt

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila egg-laying site selection as a system to study simple decision-making processes. Yang CH, et al. Science, 2008 Mar 21. PMID 18356529, Free PMC Article
    2. The tanning hormone, bursicon, does not act directly on the epidermis to tan the Drosophila exoskeleton. Flaven-Pouchon J, et al. BMC Biol, 2020 Feb 19. PMID 32075655, Free PMC Article
    3. Mechanosensitive neurons on the internal reproductive tract contribute to egg-laying-induced acetic acid attraction in Drosophila. Gou B, et al. Cell Rep, 2014 Oct 23. PMID 25373900, Free PMC Article
    4. Human type 2 diabetes mellitus-associated transcriptional disturbances in a high-sugar diet long-term exposed Drosophila melanogaster. Loreto JS, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2021 Sep. PMID 34192612
    5. Patterns of nucleotide diversity at the regions encompassing the Drosophila insulin-like peptide (dilp) genes: demography vs. positive selection in Drosophila melanogaster. Guirao-Rico S, et al. PLoS One, 2013. PMID 23308258, Free PMC Article

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila female-specific Ilp7 motoneurons are generated by Fruitless-dependent cell death in males and by a double-assurance survival role for Transformer in females.
      Title: Drosophila female-specific Ilp7 motoneurons are generated by Fruitless-dependent cell death in males and by a double-assurance survival role for Transformer in females.
    2. PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells, leading to the expression of Dilp8.
      Title: The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.
    3. A post-embryonic population of Insulin-like peptide 7 (Ilp7)-expressing neurons in the posterior ventral nerve cord that innervate the reproductive tracts and exhibit a female bias in their function, are identified.
      Title: Female-biased dimorphism underlies a female-specific role for post-embryonic Ilp7 neurons in Drosophila fertility.
    4. Surviving posterior dMP2 neurons no longer function in axonal scaffolding but differentiate into neuroendocrine cells that express insulin-like peptide 7 (Ilp7) and innervate the hindgut.
      Title: Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Insulin-like peptide 7
    Names
    CG13317-PA
    Ilp7-PA
    drosophila insulin-like peptide 7
    insulin-like peptide
    relaxin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3667621..3668845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130714.2 → NP_570070.1  Insulin-like peptide 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570070.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4Q9
      UniProtKB/TrEMBL
      D2NUH7, E7BBS6, H1UUA1, T2HXA1
      Related
      FBpp0070552
      Conserved Domains (1) summary
      cd04365
      Location:59 → 150
      IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4Q9.2 Q9W4Q9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools