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    PSP2 Psp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PSP2
    Official Full Name
    Psp2p
    Primary source
    SGD:S000004479
    Locus tag
    YML017W
    See related
    AllianceGenome:SGD:S000004479; FungiDB:YML017W; VEuPathDB:YML017W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MRS15
    Summary
    Enables mRNA binding activity. Predicted to be involved in tRNA 5'-leader removal. Located in P-body. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PSP2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (236588..238731)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase Neighboring gene uncharacterized protein Neighboring gene salt homeostasis regulator Neighboring gene TATA-binding protein-associated factor TAF11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A multitude of suppressors of group II intron-splicing defects in yeast. Waldherr M, et al. Curr Genet, 1993 Oct. PMID 8252639
    2. Suppressors of the temperature sensitivity of DNA polymerase alpha mutations in Saccharomyces cerevisiae. Formosa T, et al. Mol Gen Genet, 1998 Feb. PMID 9529527
    3. Nst1, Densely Associated to P-Body in the Post-Exponential Phases of Saccharomyces cerevisiae, Shows an Intrinsic Potential of Producing Liquid-Like Condensates of P-Body Components in Cells. Choi YJ, et al. Int J Mol Sci, 2022 Feb 24. PMID 35269643, Free PMC Article
    4. Psp2, a novel regulator of autophagy that promotes autophagy-related protein translation. Yin Z, et al. Cell Res, 2019 Dec. PMID 31666677, Free PMC Article
    5. Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae. Zhu M, et al. J Cell Sci, 2020 Jul 9. PMID 32503941

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Psp2, a novel regulator of autophagy that promotes autophagy-related protein translation.
      Title: Psp2, a novel regulator of autophagy that promotes autophagy-related protein translation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Psp2p
    NP_013695.2
    • Asn rich cytoplasmic protein with a role in clathrin suppresion; contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      236588..238731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182375.1 → NP_013695.2  TPA: Psp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013695.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZF7, P50109, Q07170, Q870H3
      UniProtKB/TrEMBL
      C8ZEI7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50109.2

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